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  Conditional modulation of spike-timing-dependent plasticity for olfactory learning

Cassenaer, S., & Laurent, G. (2012). Conditional modulation of spike-timing-dependent plasticity for olfactory learning. Nature, 482(7383), 47-52. doi:10.1038/nature10776.

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 Creators:
Cassenaer, Stijn, Author
Laurent, Gilles1, Author           
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1Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461701              

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 Abstract: Mushroom bodies are a well-known site for associative learning in insects. Yet the precise mechanisms that underlie plasticity there and ensure their specificity remain elusive. In locusts, the synapses between the intrinsic mushroom body neurons and their postsynaptic targets obey a Hebbian spike-timing-dependent plasticity (STDP) rule. Although this property homeostatically regulates the timing of mushroom body output, its potential role in associative learning is unknown. Here we show in vivo that pre-post pairing causing STDP can, when followed by the local delivery of a reinforcement-mediating neuromodulator, specify the synapses that will undergo an associative change. At these synapses, and there only, the change is a transformation of the STDP rule itself. These results illustrate the multiple actions of STDP, including a role in associative learning, despite potential temporal dissociation between the pairings that specify synaptic modification and the delivery of reinforcement-mediating neuromodulator signals.

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Language(s): eng - English
 Dates: 2012-01-25
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: eDoc: 641264
ISI: 000299726000032
DOI: 10.1038/nature10776
PMID: 22278062
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 482 (7383) Sequence Number: - Start / End Page: 47 - 52 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238