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  Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT

Stubbusch, J., Majdazari, A., Schmidt, M., Schütz, G., Deller, T., & Rohrer, H. (2011). Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT. Genesis, 49(12), 935-941.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1D03-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1D04-3
Genre: Journal Article

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 Creators:
Stubbusch, J.1, Author              
Majdazari, A.1, Author              
Schmidt, M.1, Author              
Schütz, G., Author
Deller, T., Author
Rohrer, H.1, Author              
Affiliations:
1Developmental Neurobiology Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461697              

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 Abstract: We generated transgenic mice bearing a tamoxifen-dependent Cre recombinase expressed under the control of the dopamine-beta-hydroxylase promoter. By crossing to the ROSA26 reporter mice we show that tamoxifen-induced Cre recombinase in adult mice specifically activates beta-galactosidase expression in differentiated noradrenergic neurons of the central and peripheral nervous system. Tamoxifen application in adult mice did not induce beta-galactosidase activity in parasympathetic neurons that transiently express DBH during development. Thus, this transgenic mouse line represents a valuable tool to study gene function in mature noradrenergic neurons by conditional inactivation. genesis 49:935941, 2011. (c) 2011 Wiley Periodicals, Inc.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 579125
ISI: 000297634000006
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Title: Genesis
Source Genre: Journal
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Pages: - Volume / Issue: 49 (12) Sequence Number: - Start / End Page: 935 - 941 Identifier: ISSN: 1526-954X