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  PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

Perroy, J., El Far, O., Bertaso, F., Pin, J. P., Betz, H., Bockaert, J., et al. (2002). PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. EMBO Journal, 21(12), 2990-2999.

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 Creators:
Perroy, J., Author
El Far, O.1, Author           
Bertaso, F., Author
Pin, J. P., Author
Betz, H.1, Author           
Bockaert, J., Author
Fagni, L., Author
Affiliations:
1Neurochemistry Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461704              

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Free keywords: calcium channels; mGlu receptor; PICK1; synaptic transmission
 Abstract: Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors. Here we show that the interaction of the presynaptic metabotropic glutamate (mGlu) receptor subtype. mGlu7a, with the postsynaptic density-95 disc-large zona occludens 1 (PDZ) domain-containing protein, PICK1, is required for specific inhibition of P/Q-type Ca2+ channels, in cultured cerebellar granule neurons. Furthermore, we show that activation of the presynaptic mGlu7a receptor inhibits synaptic transmission and this effect also requires the presence of PICK1. These results indicate that the scaffolding protein, PICK1, plays an essential role in the control of synaptic transmission by the mGlu7a receptor complex.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 10544
ISI: 000176587600015
 Degree: -

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Title: EMBO Journal
  Alternative Title : Embo J.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 21 (12) Sequence Number: - Start / End Page: 2990 - 2999 Identifier: ISSN: 0261-4189