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  Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens, M. C., Demissie, S., Hsu, Y.-H., Yerges-Armstrong, L. M., Chou, W.-C., Stolk, L., et al. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8: 80. doi:10.1038/s41467-017-00031-7.

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http://dx.doi.org/10.1038/s41467-017-00031-7 (Publisher version)
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Zillikens, M. Carola, Author
Demissie, Serkalem, Author
Hsu, Yi-Hsiang, Author
Yerges-Armstrong, Laura M., Author
Chou, Wen-Chi, Author
Stolk, Lisette, Author
Livshits, Gregory, Author
Broer, Linda, Author
Johnson, Toby, Author
Koller, Daniel L., Author
Kutalik, Zoltán, Author
Luan, Jian’an, Author
Malkin, Ida, Author
Ried, Janina S., Author
Smith, Albert V., Author
Thorleifsson, Gudmar, Author
Vandenput, Liesbeth, Author
Hua Zhao, Jing, Author
Zhang, Weihua, Author
Aghdassi, Ali, Author
Åkesson, Kristina, AuthorAmin, Najaf, AuthorBaier, Leslie J., AuthorBarroso, Inês, AuthorBennett, David A., AuthorBertram, Lars, AuthorBiffar, Rainer, AuthorBochud, Murielle, AuthorBoehnke, Michael, AuthorBorecki, Ingrid B., AuthorBuchman, Aron S., AuthorByberg, Liisa, AuthorCampbell, Harry, AuthorCampos Obanda, Natalia, AuthorCauley, Jane A., AuthorCawthon, Peggy M., AuthorCederberg, Henna, AuthorChen, Zhao, AuthorCho, Nam H., AuthorJin Choi, Hyung, AuthorClaussnitzer, Melina, AuthorCollins, Francis, AuthorCummings, Steven R., AuthorDe Jager, Philip L., AuthorDemuth, Ilja, AuthorDhonukshe-Rutten, Rosalie A. M., AuthorDiatchenko, Luda, AuthorEiriksdottir, Gudny, AuthorEnneman, Anke W., AuthorErdos, Mike, AuthorEriksson, Johan G., AuthorEriksson, Joel, AuthorEstrada, Karol, AuthorEvans, Daniel S., AuthorFeitosa, Mary F., AuthorFu, Mao, AuthorGarcia, Melissa, AuthorGieger, Christian, AuthorGirke, Thomas, AuthorGlazer, Nicole L., AuthorGrallert, Harald, AuthorGrewal, Jagvir, AuthorHan, Bok-Ghee, AuthorHanson, Robert L., AuthorHayward, Caroline, AuthorHofman, Albert, AuthorHoffman, Eric P., AuthorHomuth, Georg, AuthorHsueh, Wen-Chi, AuthorHubal, Monica J., AuthorHubbard, Alan, AuthorHuffman, Kim M., AuthorHusted, Lise B., AuthorIllig, Thomas, AuthorIngelsson, Erik, AuthorIttermann, Till, AuthorJansson, John-Olov, AuthorJordan, Joanne M., AuthorJula, Antti, AuthorKarlsson, Magnus, AuthorKhaw, Kay-Tee, AuthorKilpeläinen, Tuomas O., AuthorKlopp, Norman, AuthorKloth, Jacqueline S. L., AuthorKoistinen, Heikki A., AuthorKraus, William E., AuthorKritchevsky, Stephen, AuthorKuulasmaa, Teemu, AuthorKuusisto, Johanna, AuthorLaakso, Markku, AuthorLahti, Jari, AuthorLang, Thomas, AuthorLangdahl, Bente L., AuthorLauner, Lenore J., AuthorLee, Jong-Young, AuthorLerch, Markus M., AuthorLewis, Joshua R., AuthorLind, Lars, AuthorLindgren, Cecilia, AuthorLiu, Yongmei, AuthorLiu, Tian1, Author              Liu, Youfang, AuthorLjunggren, Östen, AuthorLorentzon, Mattias, AuthorLuben, Robert N., AuthorMaixner, William, AuthorMcGuigan, Fiona E., AuthorMedina-Gomez, Carolina, AuthorMeitinger, Thomas, AuthorMelhus, Håkan, AuthorMellström, Dan, AuthorMelov, Simon, AuthorMichaëlsson, Karl, AuthorMitchell, Braxton D., AuthorMorris, Andrew P., AuthorMosekilde, Leif, AuthorNewman, Anne, AuthorNielson, Carrie M., AuthorO’Connell, Jeffrey R., AuthorOostra, Ben A., AuthorOrwoll, Eric S., AuthorPalotie, Aarno, AuthorParker, Stephan, AuthorPeacock, Munro, AuthorPerola, Markus, AuthorPeters, Annette, AuthorPolasek, Ozren, AuthorPrince, Richard L., AuthorRäikkönen, Katri, AuthorRalston, Stuart H., AuthorRipatti, Samuli, AuthorRobbins, John A., AuthorRotter, Jerome I., AuthorRudan, Igor, AuthorSalomaa, Veikko, AuthorSatterfield, Suzanne, AuthorSchadt, Eric E., AuthorSchipf, Sabine, AuthorScott, Laura, AuthorSehmi, Joban, AuthorShen, Jian, AuthorSoo Shin, Chan, AuthorSigurdsson, Gunnar, AuthorSmith, Shad, AuthorSoranzo, Nicole, AuthorStančáková, Alena, AuthorSteinhagen-Thiessen, Elisabeth, AuthorStreeten, Elizabeth A., AuthorStyrkarsdottir, Unnur, AuthorSwart, Karin M. A., AuthorTan, Sian-Tsung, AuthorTarnopolsky, Mark A., AuthorThompson, Patricia, AuthorThomson, Cynthia A., AuthorThorsteinsdottir, Unnur, AuthorTikkanen, Emmi, AuthorTranah, Gregory J., AuthorTuomilehto, Jaakko, Authorvan Schoor, Natasja M., AuthorVerma, Arjun, AuthorVollenweider, Peter, AuthorVölzke, Henry, AuthorWactawski-Wende, Jean, AuthorWalker, Mark, AuthorWeedon, Michael N., AuthorWelch, Ryan, AuthorWichmann, H. Erich, AuthorWiden, Elisabeth, AuthorWilliams, Frances M. K., AuthorWilson, James F., AuthorWright, Nicole C., AuthorXie, Weijia, AuthorYu, Lei, AuthorZhou, Yanhua, AuthorChambers, John C., AuthorDöring, Angela, Authorvan Duijn, Cornelia M., AuthorEcons, Michael J., AuthorGudnason, Vilmundur, AuthorKooner, Jaspal S., AuthorPsaty, Bruce M., AuthorSpector, Timothy D., AuthorStefansson, Kari, AuthorRivadeneira, Fernando, AuthorUitterlinden, André G., AuthorWareham, Nicholas J., AuthorOssowski, Vicky, AuthorWaterworth, Dawn, AuthorLoos, Ruth J. F., AuthorKarasik, David, AuthorHarris, Tamara B., AuthorOhlsson, Claes, AuthorKiel, Douglas P., Author more..
Affiliations:
1Center for Lifespan Psychology, Max Planck Institute for Human Development, Max Planck Society, ou_2074288              

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 Abstract: Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10−8) or suggestively genome wide (p < 2.3 × 10−6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-017-00031-7
ISSN: 2041-1723
Other: alg:id10007411
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Title: Nature Communications
Source Genre: Journal
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Pages: - Volume / Issue: 8 Sequence Number: 80 Start / End Page: - Identifier: -