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  Remote control of glucose homeostasis in vivo using photopharmacology

Mehta, Z. B., Johnston, N. R., Nguyen-Tu, M.-S., Broichhagen, J., Schultz, P., Larner, D. P., et al. (2017). Remote control of glucose homeostasis in vivo using photopharmacology. Scientific Reports, 7: 291, pp. 1-11. doi:10.1038/s41598-017-00397-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-C84D-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-C84E-E
Genre: Journal Article

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ScientificRep_7_2017_291.pdf (Any fulltext), 5MB
 
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 Creators:
Mehta, Zenobia B., Author
Johnston, Natalie R., Author
Nguyen-Tu, Marie-Sophie, Author
Broichhagen, Johannes1, Author              
Schultz, Peter, Author
Larner, Dean P., Author
Leclerc, Isabelle, Author
Trauner, Dirk, Author
Rutter, Guy A., Author
Hodson, David J., Author
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects. As a proof-of-concept, we have subjected the fourth generation photoswitchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximum/repeated tolerated dose studies, as well as in vivo testing in rodents. Here, we show that JB253 is well-tolerated with minimal mutagenicity and can be used to optically-control glucose homeostasis in anesthetized mice following delivery of blue light to the pancreas. These studies provide the first demonstration that photopharmacology may one day be applicable to the light-guided treatment of type 2 diabetes and other metabolic disease states in vivo in humans.

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 Dates: 2016-08-152017-02-212017-03-22
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 Sequence Number: 291 Start / End Page: 1 - 11 Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322