English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation

Shimshek, D. R., Bus, T., Schupp, B., Jensen, V., Marx, V., Layer, L. E., et al. (2017). Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation. Frontiers in Molecular Neuroscience, 10: 214, pp. 1-11. doi:10.3389/fnmol.2017.00214.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-C931-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1125-C
Genre: Journal Article

Files

show Files
hide Files
:
FrontMolNeurosci_10_2017_214.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
FrontMolNeurosci_10_2017_214.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, Heidelberg; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Shimshek, Derya R.1, Author              
Bus, Thorsten2, Author              
Schupp, Bettina1, Author              
Jensen, Vidar, Author
Marx, Verena1, Author              
Layer, Liliana E.1, Author              
Köhr, Georg1, Author              
Sprengel, Rolf1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              

Content

show
hide
Free keywords: AMPA receptors; GluA1; GluA2; Gria1 knockout mice; Gria2 knockout mice; long-term potentiation (LTP); spatial reference memory (SRM); spatial working memory (SWM)
 Abstract: Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior.

Details

show
hide
Language(s): eng - English
 Dates: 2017-03-292017-06-192017-07-04
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Molecular Neuroscience
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 214 Start / End Page: 1 - 11 Identifier: ISSN: 1662-5099
CoNE: /journals/resource/1662-5099