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  First passage time statistics for two-channel diffusion.

Godec, A., & Metzler, R. (2017). First passage time statistics for two-channel diffusion. Journal of Physics A: Mathematical and Theoretical, 50(8): 084001. doi:10.1088/1751-8121/aa5204.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-CAA8-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-CAAB-E
Genre: Journal Article

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Godec, A.1, Author              
Metzler, R., Author
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1Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society, ou_2396692              

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 Abstract: We present rigorous results for the mean first passage time and first passage time statistics for two-channel Markov additive diffusion in a 3-dimensional spherical domain. Inspired by biophysical examples we assume that the particle can only recognise the target in one of the modes, which is shown to effect a non-trivial first passage behaviour. We also address the scenario of intermittent immobilisation. In both cases we prove that despite the perfectly non-recurrent motion of two-channel Markov additive diffusion in 3 dimensions the first passage statistics at long times do not display Poisson-like behaviour if none of the phases has a vanishing diffusion coefficient. This stands in stark contrast to the standard (one-channel) Markov diffusion counterpart. We also discuss the relevance of our results in the context of cellular signalling.

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Language(s): eng - English
 Dates: 2017-01-17
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1088/1751-8121/aa5204
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Title: Journal of Physics A: Mathematical and Theoretical
Source Genre: Journal
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Pages: 17 Volume / Issue: 50 (8) Sequence Number: 084001 Start / End Page: - Identifier: -