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  Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Zak, K. M., Grudnik, P., Magiera, K., Domling, A., Dubin, G., & Holak, T. A. (2017). Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2. Structure, 25(8), 1163-1174. doi:10.1016/j.str.2017.06.011.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D777-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D778-8
Genre: Journal Article

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 Creators:
Zak, Krzysztof M.1, Author
Grudnik, Przemyslaw1, Author
Magiera, Katarzyna1, Author
Domling, Alexander1, Author
Dubin, Grzegorz1, Author
Holak, Tad A.2, Author              
Affiliations:
1external, ou_persistent22              
2Holak, Tad / NMR Spectroscopy, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565154              

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Free keywords: PROGRAMMED DEATH 1; CANCER-IMMUNOTHERAPY; COMBINATION IMMUNOTHERAPY; ANTIBODY PEMBROLIZUMAB; CRYSTAL-STRUCTURE; BREAST-CANCER; B7 FAMILY; BLOCKADE; THERAPY; COMPLEXBiochemistry & Molecular Biology; Biophysics; Cell Biology;
 Abstract: Cancer cells can avoid and suppress immune responses through activation of inhibitory immune checkpoint proteins, such as PD-1, PD-L1, and CTLA-4. Blocking the activities of these proteins with monoclonal antibodies, and thus restoring T cell function, has delivered breakthrough therapies against cancer. In this review, we describe the latest work on structural characterization of the checkpoint proteins, their interactions with cognate ligands and with therapeutic antibodies. Structures of the extracellular portions of these proteins reveal that they all have a similar modular structure, composed of small domains similar in topology to the domains found in antibodies. Structural basis for blocking the PD-1/PD-L1 interaction by small molecules is illustrated with the compound BMS-202 that binds to and induces dimerization of PD-L1.

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Language(s): eng - English
 Dates: 2017-08-012017
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000406744600001
DOI: 10.1016/j.str.2017.06.011
 Degree: -

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Title: Structure
  Other : Structure
Source Genre: Journal
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Publ. Info: London : Cell Press
Pages: - Volume / Issue: 25 (8) Sequence Number: - Start / End Page: 1163 - 1174 Identifier: ISSN: 0969-2126
CoNE: https://pure.mpg.de/cone/journals/resource/954927002244_1