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  MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila

Laugks, U., Hieke, M., & Wagner, N. (2017). MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila. Cellular and Molecular Neurobiology, 37(6), 1077-1093. doi:10.1007/s10571-016-0442-4.

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 Creators:
Laugks, Ulrike1, Author              
Hieke, Marie2, Author
Wagner, Nicole2, Author
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
2external, ou_persistent22              

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Free keywords: INNER NUCLEAR-MEMBRANE; BUSCHKE-OLLENDORFF-SYNDROME; LEM-DOMAIN PROTEINS; NEUROMUSCULAR-JUNCTION; II RECEPTOR; ENDOCYTOSIS; FAMILY; INTERACTS; INSIGHTS; ZONECell Biology; Neurosciences & Neurology;
 Abstract: Bone morphogenic protein (BMP) signaling is crucial for coordinated synaptic growth and plasticity. Here, we show that the nuclear LEM-domain protein MAN1 is a negative regulator of synaptic growth at Drosophila larval and adult neuromuscular junctions (NMJs). Loss of MAN1 is associated with synaptic structural defects, including floating T-bars, membrane attachment defects, and accumulation of vesicles between perisynaptic membranes and membranes of the subsynaptic reticulum. In addition, MAN1 mutants accumulate more heterogeneously sized vesicles and multivesicular bodies in larval and adult synapses, the latter indicating that MAN1 may function in synaptic vesicle recycling and endosome-to-lysosome trafficking. Synaptic overgrowth in MAN1 is sensitive to BMP signaling levels, and loss of key BMP components attenuate BMP-induced synaptic overgrowth. Based on these observations, we propose that MAN1 negatively regulates accumulation and distribution of BMP signaling components to ensure proper synaptic growth and integrity at larval and adult NMJs.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000404640100012
DOI: 10.1007/s10571-016-0442-4
 Degree: -

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Title: Cellular and Molecular Neurobiology
  Other : Cell. Mol. Neurobiol.
Source Genre: Journal
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Publ. Info: New York, NY : Kluwer Academic/Plenum Publishers
Pages: - Volume / Issue: 37 (6) Sequence Number: - Start / End Page: 1077 - 1093 Identifier: ISSN: 0272-4340
CoNE: https://pure.mpg.de/cone/journals/resource/954925503218