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  The endoplasmic reticulum: A hub of protein quality control in health and disease

Vincenz-Donnelly, L., & Hipp, M. S. (2017). The endoplasmic reticulum: A hub of protein quality control in health and disease. Free Radical Biology and Medicine, 108, 383-393. doi:10.1016/j.freeradbiomed.2017.03.031.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DD2E-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DF71-9
Genre: Journal Article

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Vincenz-Donnelly and Hipp.pdf (Postprint), 802KB
 
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 Creators:
Vincenz-Donnelly, Lisa1, Author              
Hipp, Mark S.1, Author              
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Free keywords: MARINESCO-SJOGREN-SYNDROME; REGULATED STRESS-PROTEIN; UBIQUITIN LIGASE COMPLEX; TO-CYTOSOL DISLOCATION; BIP ATPASE MUTANTS; I MEMBRANE-PROTEIN; N-TERMINAL DOMAIN; FACTOR-KAPPA-B; ER-STRESS; TRANSCRIPTION FACTORBiochemistry & Molecular Biology; Endocrinology & Metabolism; Quality control; Endoplasmic reticulum; Proteostasis;
 Abstract: One third of the eukaryotic proteome is synthesized at the endoplasmic reticulum (ER), whose unique properties provide a folding environment substantially different from the cytosol. A healthy, balanced proteome in the ER is maintained by a network of factors referred to as the ER quality control (ERQC) machinery. This network consists of various protein folding chaperones and modifying enzymes, and is regulated by stress response pathways that prevent the build-up as well as the secretion of potentially toxic and aggregation-prone misfolded protein species. Here, we describe the components of the ERQC machinery, investigate their response to different forms of stress, and discuss the consequences of ERQC break-down.

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Language(s): eng - English
 Dates: 2017-03-292017
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Project name : Grant FP7 GA ERC-2012-SyG_318987–ToPAG
Grant ID : 318987
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

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Title: Free Radical Biology and Medicine
Source Genre: Journal
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Publ. Info: New York : Pergamon
Pages: - Volume / Issue: 108 Sequence Number: - Start / End Page: 383 - 393 Identifier: ISSN: 0891-5849
CoNE: https://pure.mpg.de/cone/journals/resource/954928624318