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  The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination

Lademann, C. A., Renkawitz, J., Pfander, B., & Jentsch, S. (2017). The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination. Cell Reports, 19(7), 1294-1303. doi:10.1016/j.celrep.2017.04.051.

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 Creators:
Lademann, Claudio A.1, Author              
Renkawitz, Jörg1, Author              
Pfander, Boris2, Author              
Jentsch, Stefan1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565156              
2Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565165              

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Free keywords: DOUBLE-STRAND BREAK; DNA END RESECTION; SACCHAROMYCES-CEREVISIAE; CHROMATIN REMODELERS; GENOME INTEGRITY; DISTINCT ROLES; REPAIR; FUN30; CHOICE; PHOSPHORYLATIONCell Biology;
 Abstract: The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the causes of the HR defect in INO80-C mutant cells are controversial. Here, we unite previous findings using a system to study HR with high spatial resolution in budding yeast. We find that INO80-C has at least two distinct functions during HR-DNA end resection and presynaptic filament formation. Importantly, the second function is linked to the histone variant H2A.Z. In the absence of H2A.Z, presynaptic filament formation and HR are restored in INO80-C-deficient mutants, suggesting that presynaptic filament formation is the crucial INO80-C function during HR.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 10
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Project name : ERC-2013-AdG-339176
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Funding organization : European Research Council

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Title: Cell Reports
Source Genre: Journal
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Pages: - Volume / Issue: 19 (7) Sequence Number: - Start / End Page: 1294 - 1303 Identifier: Other: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247