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  Cell-free protein synthesis in micro compartments: building a minimal cell from biobricks.

Jia, H., Heymann, M., Bernhard, F., Schwille, P., & Kai, L. (2017). Cell-free protein synthesis in micro compartments: building a minimal cell from biobricks. New biotechnology, 39(Part B), 199-205. doi:10.1016/j.nbt.2017.06.014.

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Genre: Journal Article
Other : In Press, Corrected Proof

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 Creators:
Jia, Haiyang1, Author              
Heymann, Michael1, Author              
Bernhard, Frank2, Author
Schwille, Petra1, Author              
Kai, Lei1, Author              
Affiliations:
1Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              
2external, ou_persistent22              

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 Abstract: The construction of a minimal cell that exhibits the essential characteristics of life is a great challenge in the field of synthetic biology. Assembling a minimal cell requires multidisciplinary expertise from physics, chemistry and biology. Scientists from different backgrounds tend to define the essence of 'life' differently and have thus proposed different artificial cell models possessing one or several essential features of living cells. Using the tools and methods of molecular biology, the bottom-up engineering of a minimal cell appears in reach. However, several challenges still remain. In particular, the integration of individual sub-systems that is required to achieve a self-reproducing cell model presents a complex optimization challenge. For example, multiple self-organization and self-assembly processes have to be carefully tuned. We review advances and developments of new methods and techniques, for cell-free protein synthesis as well as micro-fabrication, for their potential to resolve challenges and to accelerate the development of minimal cells. Copyright 2017 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2017-07-062017
 Publication Status: Published in print
 Pages: -
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 Identifiers: ISI: 28690157
DOI: 10.1016/j.nbt.2017.06.014
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Project name : GRK2062 Molecular Principles of Synthetic Biology
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: New biotechnology
Source Genre: Journal
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Pages: - Volume / Issue: 39 (Part B) Sequence Number: - Start / End Page: 199 - 205 Identifier: ISSN: 1876-4347