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  AIDing-targeted protein degradation in Drosophila

Zhang, X., & Schnorrer, F. (2017). AIDing-targeted protein degradation in Drosophila. The FEBS Journal, 284(8), 1178-1181. doi:10.1111/febs.14054.

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Genre: Journal Article
Other : Commentary

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 Creators:
Zhang, Xu1, Author              
Schnorrer, Frank1, Author              
Affiliations:
1Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565168              

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Free keywords: DEGRON SYSTEM; LOCALIZATION; DEPLETION; CLEAVAGE; TOOLBiochemistry & Molecular Biology;
 Abstract: Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000400358900004
DOI: 10.1111/febs.14054
 Degree: -

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Title: The FEBS Journal
  Other : The Federation if European Biochemical Societies Journal
Source Genre: Journal
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Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: 284 (8) Sequence Number: - Start / End Page: 1178 - 1181 Identifier: ISSN: 1742-464X
CoNE: https://pure.mpg.de/cone/journals/resource/954925398485