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  Impairment in predictive processes during auditory mismatch negativity in ScZ: Evidence from event-related fields

Sauer, A., Zeev-Wolf, M., Grent-’t-Jong, T., Recasens, M., Wacongne, C., Wibral, M., et al. (2017). Impairment in predictive processes during auditory mismatch negativity in ScZ: Evidence from event-related fields. Human Brain Mapping, 38(10), 5082-5093. doi:10.1002/hbm.23716.

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 Creators:
Sauer, Andreas1, 2, Author
Zeev-Wolf, Maor3, Author
Grent-’t-Jong, Tineke4, Author
Recasens, Marc4, Author
Wacongne, Catherine5, Author
Wibral, Michael6, Author
Helbling, Saskia7, Author              
Peled, Abraham8, 9, Author
Grinshpoon, Alexander8, 9, Author
Singer, Wolf1, 2, 10, Author
Goldstein, Abraham3, Author
Uhlhaas, Peter J.1, 2, 4, Author
Affiliations:
1Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany, ou_persistent22              
2Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany, ou_persistent22              
3Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel, ou_persistent22              
4Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom, ou_persistent22              
5The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
6Brain Imaging Centre, Goethe University, Frankfurt, ou_persistent22              
7Institute of Medical Psychology, Goethe University, Frankfurt, ou_persistent22              
8Shaar Menashe Mental Health Center, Haifa, Israel, ou_persistent22              
9Ruth and Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel, ou_persistent22              
10Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt, ou_persistent22              

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Free keywords: Auditory perception; Magnetoencephalograpghy; Schizophrenia; Sensory predictions
 Abstract: Patients with schizophrenia (ScZ) show pronounced dysfunctions in auditory perception but the underlying mechanisms as well as the localization of the deficit remain unclear. To examine these questions, the current study examined whether alterations in the neuromagnetic mismatch negativity (MMNm) in ScZ-patients could involve an impairment in sensory predictions in local sensory and higher auditory areas. Using a whole-head MEG-approach, we investigated the MMNm as well as P300m and N100m amplitudes during a hierarchical auditory novelty paradigm in 16 medicated ScZ-patients and 16 controls. In addition, responses to omitted sounds were investigated, allowing for a critical test of the predictive coding hypothesis. Source-localization was performed to identify the generators of the MMNm, omission responses as well as the P300m. Clinical symptoms were examined with the positive and negative syndrome scale. Event-related fields (ERFs) to standard sounds were intact in ScZ-patients. However, the ScZ-group showed a reduction in the amplitude of the MMNm during both local (within trials) and global (across trials) conditions as well as an absent P300m at the global level. Importantly, responses to sound omissions were reduced in ScZ-patients which overlapped both in latency and generators with the MMNm sources. Thus, our data suggest that auditory dysfunctions in ScZ involve impaired predictive processes that involve deficits in both automatic and conscious detection of auditory regularities.

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Language(s): eng - English
 Dates: 2017-06-122015-11-272017-06-212017-07-052017-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23716
PMID: 28677252
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : 1071
Funding program : -
Funding organization : German-Israeli Foundation for Scientific Research and Development

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 38 (10) Sequence Number: - Start / End Page: 5082 - 5093 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686