English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Single cell phenotyping reveals heterogeneity among haematopoietic stem cells following infection.

MacLean, A. L., Smith, M. A., Liepe, J., Sim, A., Khorshed, R., Rashidi, N. M., et al. (2017). Single cell phenotyping reveals heterogeneity among haematopoietic stem cells following infection. Stem Cells, 35(11), 2292-2304. doi:10.1002/stem.2692.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D18D-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-19A2-0
Genre: Journal Article

Files

show Files
hide Files
:
2473158.pdf (Publisher version), 1001KB
Name:
2473158.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
:
2473158_Suppl_1.pdf (Supplementary material), 2MB
Name:
2473158_Suppl_1.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2473158_Suppl_2.pdf (Supplementary material), 282KB
Name:
2473158_Suppl_2.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2473158_Suppl_3.pdf (Supplementary material), 41KB
Name:
2473158_Suppl_3.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2473158_Suppl_4.pdf (Supplementary material), 41KB
Name:
2473158_Suppl_4.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
MacLean, A. L., Author
Smith, M. A., Author
Liepe, J.1, Author              
Sim, A., Author
Khorshed, R., Author
Rashidi, N. M., Author
Scherf, N., Author
Kinner, A., Author
Roeder, I., Author
Lo Celso, C., Author
Stumpf, M. P. H., Author
Affiliations:
1Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_2466694              

Content

show
hide
Free keywords: -
 Abstract: The haematopoietic stem cell (HSC) niche provides essential micro-environmental cues for the production and maintenance of HSCs within the bone marrow. During inflammation, haematopoietic dynamics are perturbed, but it is not known whether changes to the HSC-niche interaction occur as a result. We visualise HSCs directly in vivo, enabling detailed analysis of the 3D niche dynamics and migration patterns in murine bone marrow following Trichinella spiralis infection. Spatial statistical analysis of these HSC trajectories reveals two distinct modes of HSC behaviour: (i) a pattern of revisiting previously explored space, and (ii) a pattern of exploring new space. Whereas HSCs from control donors predominantly follow pattern (i), those from infected mice adopt both strategies. Using detailed computational analyses of cell migration tracks and life-history theory, we show that the increased motility of HSCs following infection can, perhaps counterintuitively, enable mice to cope better in deteriorating HSC-niche micro-environments following infection.

Details

show
hide
Language(s): eng - English
 Dates: 2017-09-242017-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/stem.2692
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Stem Cells
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 35 (11) Sequence Number: - Start / End Page: 2292 - 2304 Identifier: -