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  The phase (trans)formation and physical state of a model drug in mesoscopic confinement.

Ukmar, T., Godec, A., Planinsek, O., Kaucic, V., Mali, G., & Gaberscek, M. (2011). The phase (trans)formation and physical state of a model drug in mesoscopic confinement. Physical Chemistry Chemical Physics, 13(35), 16046-16054. doi:10.1039/c1cp20874h.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D642-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D647-B
Genre: Journal Article

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 Creators:
Ukmar, T., Author
Godec, A.1, Author              
Planinsek, O., Author
Kaucic, V., Author
Mali, G., Author
Gaberscek, M., Author
Affiliations:
1Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society, ou_2396692              

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 Abstract: Compounds embedded into mesoporous or even microporous matrices are interesting for many emerging applications, such as novel catalysts, sensors, batteries, hydrogen storage materials or modern drug delivery devices. We report on two unexpected phenomena regarding the structural and dynamic properties of a model drug substance (indomethacin) when confined in mesoscopic matrices. Firstly, we show that the confinement directs the crystallization of the drug into a stable polymorph that is not otherwise formed at all; its relative amount depends on the pore size. This phenomenon is also explained theoretically using a modified classical heterogeneous nucleation theory. Secondly, we demonstrate that-even at relatively low volume fractions-the confined drug forms a condensed phase in a way that obstructs the passage of the pore channels. This may have far-reaching consequences for understanding the mechanisms of drug release from porous matrices.

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Language(s): eng - English
 Dates: 2011-08-082011
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c1cp20874h
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Title: Physical Chemistry Chemical Physics
Source Genre: Journal
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Pages: - Volume / Issue: 13 (35) Sequence Number: - Start / End Page: 16046 - 16054 Identifier: -