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  The relation between the interfacial contact and SiO2 coating efficiency and properties in the case of two clarithromycin polymorphs.

Maver, U., Znidarsic, A., Saboti, D., Srcic, S., Gaberscek, M., Godec, A., et al. (2010). The relation between the interfacial contact and SiO2 coating efficiency and properties in the case of two clarithromycin polymorphs. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 371(1-3), 119-125. doi:10.1016/j.colsurfa.2010.09.016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D665-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D673-9
Genre: Journal Article

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2473777.pdf (Publisher version), 972KB
 
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 Creators:
Maver, U., Author
Znidarsic, A., Author
Saboti, D., Author
Srcic, S., Author
Gaberscek, M., Author
Godec, A.1, Author              
Planinsek , O., Author
Affiliations:
1Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society, ou_2396692              

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Free keywords: Coating; Sol-gel; Silica; Interfacial contact; Clarithromycin; Nucleation theory
 Abstract: Two clarithromycin polymorphs with very similar particle size and morphology were coated with silica using a base-catalyzed sol-gel procedure. It was found that the contact angles, evaluated from measured surface free energies, correlate well with coating efficiency. The connection between interfacial contact (described with the contact angle), nucleation kinetics and coating performance was established using the heterogeneous nucleation theory. The resulting coating thickness and morphology were evaluated by means of thermal analysis. X-ray powder diffraction and scanning electron microscopy. Good agreement was found between the theoretical predictions and experimental findings.

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Language(s): eng - English
 Dates: 2010-09-182010-11-20
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.colsurfa.2010.09.016
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Title: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Source Genre: Journal
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Pages: - Volume / Issue: 371 (1-3) Sequence Number: - Start / End Page: 119 - 125 Identifier: -