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  Vitrification from solution in restricted space: Formation and stabilization of amorphous nifedipine in a nanoporous silica xerogel carrier.

Godec, A., Maver, U., Bele, M., Planinsek, O., Srcic, S., Gaberscek, M., et al. (2007). Vitrification from solution in restricted space: Formation and stabilization of amorphous nifedipine in a nanoporous silica xerogel carrier. International Journal of Pharmaceutics, 343(1-2), 131-140. doi:10.1016/j.ijpharm.2007.05.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D856-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-D85A-4
Genre: Journal Article

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2474004.pdf (Publisher version), 444KB
 
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Godec, A.1, Author              
Maver, U., Author
Bele, M., Author
Planinsek, O., Author
Srcic, S., Author
Gaberscek, M.cek, Author
Jamnik, J., Author
Affiliations:
1Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society, ou_2396692              

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Free keywords: thermodynamics; nucleation; amorphous drugs; structural stabilization; porous carriers
 Abstract: Purpose: The goal was to find thermodynamic criteria that must be satisfied in order to prevent formation of crystalline state of drugs within a confined space (e.g., nanopores of inorganic solid). Similarly, criteria that lead to stabilization of amorphous drug within such pores were investigated. Methods: In the theoretical part, the classical thermodynamics of nucleation is applied to the conditions of a restricted space. The theoretical findings are verified using porous silica as a carrier and nifedipine as a model drug. The amorphicity of the latter is checked using XRD and thermal analysis (DTA, DSC) in combination with BET measurements. Results: It is shown that there exists a critical pore radius of a host below which the entrapped substance will solidify in an amorphous form. There also exists a critical pore radius below which the entrapped amorphous solid will not be able to crystallize. Specifically, incorporation of NIF into a silica xerogel with an average pore diameter of about 2.5 nm produces and stabilizes its amorphous form. Conclusion: Entrapment of drugs into solid nanoporous carriers could be regarded as a potentially useful and simple method for production and/or stabilization of non-crystalline forms of a wide range of drugs.

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Language(s): eng - English
 Dates: 2007-05-182007-10-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.ijpharm.2007.05.022
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Title: International Journal of Pharmaceutics
Source Genre: Journal
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Pages: - Volume / Issue: 343 (1-2) Sequence Number: - Start / End Page: 131 - 140 Identifier: -