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  Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration

Deng, J., Zhao, C., Spatz, J. P., Wei, Q., & Spatz, J. P. (2017). Nanopatterned adhesive, stretchable hydrogel to control ligand spacing and regulate cell spreading and migration. ACS Nano, 11(8), 8282-8291. doi:10.1021/acsnano.7b03449.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-DA4A-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-8993-C
Genre: Journal Article

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 Creators:
Deng, Jie1, 2, Author
Zhao, Changseng, Author
Spatz, Joachim P.1, 2, Author           
Wei, Qiang1, 2, Author           
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: cell adhesion; cell migration; heterogeneous interface; interligand spacing; nanopattern; stretchable hydrogel
 Abstract: Spatial molecular patterning enables the regulation of adhesion receptor clustering and can thus play a pivotal role in multiple biological activities such as cell adhesion, viability, proliferation, and differentiation. A wide range of nanopatterned, adhesive interfaces have been designed to decipher the essence of molecular-scale interactions between cells and the adhesive interface. Although an interligand spacing of less than 70 nm is a proven prerequisite for the formation of stable focal adhesions, there is a paucity of data concerning how cells behave on substrates featuring heterogeneous adhesiveness. In this study, a stretchable hydrogel functionalized with a quasi-hexagonally arranged nanoarray was stretched along one direction, resulting in ligands periodically arranged in a pattern resembling a centered rectangular lattice with an interligand spacing smaller than 70 nm in one direction and greater than 70 nm in the orthogonal direction. This substrate was utilized to modulate interligand spacing and investigate cell adhesion and migration. An interligand spacing larger than 70 nm-even in just one direction-prevented the establishment of stable focal adhesions. The stretched interface promoted dynamic remodeling at cell contacts, resulting in higher cellular mobility. Our nanopatterned stretchable hydrogel permits reversible control over cell adhesion and migration on nanopatterned ligand interfaces.

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Language(s): eng - English
 Dates: 2017-05-172017-07-112017-07-112017-08-22
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/acsnano.7b03449
URI: https://www.ncbi.nlm.nih.gov/pubmed/28696653
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Title: ACS Nano
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 11 (8) Sequence Number: - Start / End Page: 8282 - 8291 Identifier: ISSN: 1936-0851
CoNE: https://pure.mpg.de/cone/journals/resource/1936-0851