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  Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets

Lang, E., Mallien, A. S., Vasilescu, A.-N., Hefter, D., Luoni, A., Riva, M. A., et al. (2018). Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets. Neuroscience and Biobehavioral Reviews, 84, 352-358. doi:10.1016/j.neubiorev.2017.08.012.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DB91-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C139-4
Genre: Journal Article

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NeurosciBiobehavRev_84_2017_352.pdf (Any fulltext), 179KB
 
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 Creators:
Lang, Elisabeth, Author
Mallien, Anne S., Author
Vasilescu, Andrei-Nicolae, Author
Hefter, Dimitri, Author
Luoni, Alessia, Author
Riva, Marco A., Author
Borgwardt, Stefan, Author
Sprengel, Rolf1, Author              
Lang, Undine E., Author
Gass, Peter, Author
Inta, Dragos, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: NMDA receptors; Depression; Molecular biology; GluN2 subunits; Ketamine; Glutamate
 Abstract: A growing body of evidence supports the idea that drugs targeting the glutamate system may represent a valuable therapeutic alternative in major depressive disorders (MDD). The rapid and prolonged mood elevating effect of the NMDA receptor (NMDAR) antagonist ketamine has been studied intensely. However, its clinical use is hampered by deleterious side-effects, such as psychosis. Therefore, a better understanding of the mechanisms of the psychotropic effects after NMDAR blockade is necessary to develop glutamatergic antidepressants with improved therapeutic profile. Here we review recent experimental data that addressed molecular/cellular determinants of the antidepressant effect mediated by inactivating NMDAR subtypes. We refer to results obtained both in pharmacological and genetic animal models, ranging from global to conditional NMDAR manipulation. Our main focus is on the contribution of different NMDAR subtypes to the psychoactive effects induced by NMDAR ablation/blockade. We review data analyzing the effect of NMDAR subtype deletions limited to specific neuronal populations/brain areas in the regulation of mood. Altogether, these studies suggest effective and putative specific NMDAR drug targets for MDD treatment.

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Language(s): eng - English
 Dates: 2017-07-262017-04-292017-08-172017-08-232018-01-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neubiorev.2017.08.012
 Degree: -

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Title: Neuroscience and Biobehavioral Reviews
Source Genre: Journal
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Publ. Info: New York [etc.] : Pergamon
Pages: - Volume / Issue: 84 Sequence Number: - Start / End Page: 352 - 358 Identifier: ISSN: 0149-7634
CoNE: https://pure.mpg.de/cone/journals/resource/954928536106