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  Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

Kougioumtzidou, E., Shimizu, T., Hamilton, N. B., Tohyama, K., Sprengel, R., Monyer, H., et al. (2017). Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival. eLife, 6: e28080, pp. 1-31. doi:10.7554/eLife.28080.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DBAB-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DBAC-1
Genre: Journal Article

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 Creators:
Kougioumtzidou, Eleni, Author
Shimizu, Takahiro, Author
Hamilton, Nicola B, Author
Tohyama, Koujiro, Author
Sprengel, Rolf1, Author              
Monyer, Hannah, Author
Attwell, David, Author
Richardson, William D, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AMPA receptor; conditional knockout; developmental biology; glutamate; internode length; mouse; neuroscience; oligodendrocyte; stem cells; survival
 Abstract: Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3 and GluA4. We generated mice in which OPs lack both GluA2 and GluA3, or all three subunits GluA2/3/4, which respectively reduced or abolished AMPAR-mediated input to OPs. In both double- and triple-knockouts OP proliferation and number were unchanged but ~25% fewer oligodendrocytes survived in the subcortical white matter during development. In triple knockouts, this shortfall persisted into adulthood. The oligodendrocyte deficit resulted in ~20% fewer myelin sheaths but the average length, number and thickness of myelin internodes made by individual oligodendrocytes appeared normal. Thus, AMPAR-mediated signalling from active axons stimulates myelin production in developing white matter by enhancing oligodendrocyte survival, without influencing myelin synthesis per se.

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Language(s): eng - English
 Dates: 2017-04-252017-06-072017-06-13
 Publication Status: Published online
 Pages: 31
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 6 Sequence Number: e28080 Start / End Page: 1 - 31 Identifier: Other: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X