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  Using resting-state fMRI to assess the effect of aerobic exercise on functional connectivity of the DLPFC in older overweight adults

Prehn, K., Lesemann, A., Krey, G., Witte, V., Köbe, T., Grittner, U., et al. (2019). Using resting-state fMRI to assess the effect of aerobic exercise on functional connectivity of the DLPFC in older overweight adults. Brain and Cognition, 131, 34-44. doi:10.1016/j.bandc.2017.08.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DC36-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B336-6
Genre: Journal Article

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 Creators:
Prehn, Kristin1, Author
Lesemann, Anne1, Author
Krey, Georgia1, Author
Witte, Veronica1, 2, Author              
Köbe, Theresa1, Author
Grittner, Ulrike3, 4, Author
Flöel, Agnes1, 4, 5, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Biostatistics and Clinical Epidemiology, Charité University Medicine Berlin, Germany, ou_persistent22              
4Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              

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Free keywords: Aerobic exercise; Aging; Resting-state fMRI; DLPFC; Task-switching
 Abstract: Cardiovascular fitness is thought to exert beneficial effects on brain function and might delay the onset of cognitive decline. Empirical evidence of exercise-induced cognitive enhancement, however, has not been conclusive, possibly due to short intervention times in clinical trials. Resting-state functional connectivity (RSFC) has been proposed as an early indicator for intervention-induced changes. Here, we conducted a study in which healthy older overweight subjects took either part in a moderate aerobic exercise program over 6 months (AE group; n = 11) or control condition of non-aerobic stretching and toning (NAE group; n = 18). While cognitive and gray matter volume changes were rather small (i.e., appeared only in certain sub-scores without Bonferroni correction for multiple comparisons or using small volume correction), we found significantly increased RSFC after training between dorsolateral prefrontal cortex and superior parietal gyrus/precuneus in the AE compared to the NAE group. This intervention study demonstrates an exercise-induced modulation of RSFC between key structures of the executive control and default mode networks, which might mediate an interaction between task-positive and task-negative brain activation required for task switching. Results further emphasize the value of RSFC as a sensitive biomarker for detecting early intervention-related cognitive improvements in clinical trials.

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Language(s): eng - English
 Dates: 2017-08-112017-04-252017-08-122017-08-232019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.bandc.2017.08.006
PMID: 28844505
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : Fl 379-10/1 ; Fl 379-11/1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 0315673A ; 01EO0801 ; 01GQ1424A ; 01GQ1420B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: Brain and Cognition
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 131 Sequence Number: - Start / End Page: 34 - 44 Identifier: ISSN: 0278-2626
CoNE: https://pure.mpg.de/cone/journals/resource/954922648105