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  Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease

Saenger, V. M., Kahan, J., Foltynie, T., Friston, K., Aziz, T. Z., Green, A. L., et al. (2017). Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease. Scientific Reports, 7: 9882. doi:10.1038/s41598-017-10003-y.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DD47-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B85B-8
Genre: Journal Article

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 Creators:
Saenger, Victor M.1, Author
Kahan, Joshua2, Author
Foltynie, Tom2, Author
Friston, Karl3, Author
Aziz, Tipu Z.4, 5, Author
Green, Alexander L.4, 5, Author
van Hartevelt, Tim J.6, 7, Author
Cabral, Joana6, 7, 8, Author
Stevner, Angus B. A.6, 7, Author
Fernandes, Henrique M.6, 7, Author
Mancini, Laura9, Author
Thornton, John9, Author
Yousry, Tarek9, Author
Limosin, Patricia2, Author
Zrinzo, Ludvic2, Author
Hariz, Marwan2, Author
Marques, Paulo8, 10, 11, Author
Sousa, Nuno8, 10, 11, Author
Kringelbach, Morten L.6, 7, Author
Deco, Gustavo1, 12, 13, 14, Author              
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
4Nuffield Department Clinical Neurosciences, University of Oxford, United Kingdom, ou_persistent22              
5Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom, ou_persistent22              
6Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
7Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
8ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
9Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ou_persistent22              
10ICVS/3B’s - PT Government Associate Laboratory, Braga, Portugal, ou_persistent22              
11Clinical Academic Center, Braga, Portugal, ou_persistent22              
12Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
13Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
14School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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 Abstract: Deep brain stimulation (DBS) for Parkinson’s disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson’s disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments.

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Language(s): eng - English
 Dates: 2016-12-052017-06-282017-08-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-017-10003-y
PMID: 28851996
PMC: PMC5574998
 Degree: -

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 Sequence Number: 9882 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322