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  Model-based control in dimensional psychiatry

Voon, V., Reiter, A., Sebold, M., & Groman, S. (2017). Model-based control in dimensional psychiatry. Biological Psychiatry, 82(6), 391-400. doi:10.1016/j.biopsych.2017.04.006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-DE64-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C90A-0
Genre: Journal Article

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 Creators:
Voon, Valerie1, 2, Author
Reiter, Andrea3, 4, Author              
Sebold, Miriam5, Author
Groman, Stephanie6, Author
Affiliations:
1Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
2Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom, ou_persistent22              
3Lifespan Developmental Neuroscience, Department of Psychology, TU Dresden, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
6Department of Psychiatry, Yale University, New Haven, CT, USA, ou_persistent22              

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Free keywords: Addictions; Binge eating; Compulsivity; Computational psychiatry; Goal-directed control; Habit; Model-based control; Obsessive-compulsive disorder
 Abstract: We use parallel interacting goal-directed and habitual strategies to make our daily decisions. The arbitration between these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders. Goal-directed control, also known as model-based control, is based on an affective outcome relying on a learned internal model to prospectively make decisions. In contrast, habit control, also known as model-free control, is based on an integration of previous reinforced learning autonomous of the current outcome value and is implicit and more efficient but at the cost of greater inflexibility. The concept of model-based control can be further extended into pavlovian processes. Here we describe and compare tasks that tap into these constructs and emphasize the clinical relevance and translation of these tasks in psychiatric disorders. Together, these findings highlight a role for model-based control as a transdiagnostic impairment underlying compulsive behaviors and representing a promising therapeutic target.

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Language(s): eng - English
 Dates: 2017-04-112016-12-142017-04-122017-04-232017-09-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.biopsych.2017.04.006
PMID: 28599832
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : -
Funding program : Medical Research Council Senior Clinical Fellowship
Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

Source 1

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Title: Biological Psychiatry
  Other : Biol. Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 82 (6) Sequence Number: - Start / End Page: 391 - 400 Identifier: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111