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  The inhibition by β-adrenoceptor blocking agents of calcium uptake into and efflux from isolated sarcoplasmic vesicles

Temple, D. M., Hasselbach, W., & Makinose, M. (1974). The inhibition by β-adrenoceptor blocking agents of calcium uptake into and efflux from isolated sarcoplasmic vesicles. Naunyn-Schmiedeberg's Archives of Pharmacology, 39, 187-194. doi:10.1007/BF00499033.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-DF67-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-DF68-0
Genre: Journal Article

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ArchPharmacol_282_1974_187.pdf (Any fulltext), 442KB
 
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https://link.springer.com/content/pdf/10.1007%2FBF00499033.pdf (Any fulltext)
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 Creators:
Temple, Diana M., Author
Hasselbach, Wilhelm1, Author           
Makinose, Madoka2, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
2Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Calcium; β-Adrenoceptor Blocker; Adenosine Triphosphatase; Nucleotides; Sarcoplasmic Reticulum
 Abstract: The rates of calcium uptake and the calcium dependent increase in ATPase activity of sarcoplasmic reticulum vesicles isolated from rabbit skeletal muscle are reduced in the same ratio by the β-adrenoceptor blocking agents propranolol, pronethalol and Ro-03,3528, but neither by practolol, sotalol nor oxprenolol. The total calcium accumulated was affected by none of the inhibitors. The inhibitory potency of these compounds upon the calcium pump appears to be correlated with their membrane activity or potency as local anaesthetic agents, rather than with their β-adrenoceptor blocking potency. Like the rate of calcium uptake the rate of calcium efflux from the sarcoplasmic vesicles in the presence of ADP, GPD and UDP together with phosphate is inhibited by propranolol and pronethalol.

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Language(s): eng - English
 Dates: 1973-12-061974-06
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00499033
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Title: Naunyn-Schmiedeberg's Archives of Pharmacology
Source Genre: Journal
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Publ. Info: Berlin ; Heidelberg : Springer
Pages: - Volume / Issue: 39 Sequence Number: - Start / End Page: 187 - 194 Identifier: ISSN: 1432-1912