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  Fluorescence nanoscopy in cell biology.

Sahl, S. J., Hell, S. W., & Jakobs, S. (2017). Fluorescence nanoscopy in cell biology. Nature Reviews Molecular Cell Biology, 18(11), 685-701. doi:10.1038/nrm.2017.71.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-E296-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-A4E1-6
Genre: Journal Article

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 Creators:
Sahl, S. J.1, Author              
Hell, S. W.1, Author              
Jakobs, S.2, Author              
Affiliations:
1Department of NanoBiophotonics, MPI for biophysical chemistry, Max Planck Society, ou_578627              
2Research Group of Mitochondrial Structure and Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578566              

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 Abstract: Fluorescence nanoscopy uniquely combines minimally invasive optical access to the internal nanoscale structure and dynamics of cells and tissues with molecular detection specificity. While the basic physical principles of 'super-resolution' imaging were discovered in the 1990s, with initial experimental demonstrations following in 2000, the broad application of super-resolution imaging to address cell-biological questions has only more recently emerged. Nanoscopy approaches have begun to facilitate discoveries in cell biology and to add new knowledge. One current direction for method improvement is the ambition to quantitatively account for each molecule under investigation and assess true molecular colocalization patterns via multi-colour analyses. In pursuing this goal, the labelling of individual molecules to enable their visualization has emerged as a central challenge. Extending nanoscale imaging into (sliced) tissue and whole-animal contexts is a further goal. In this Review we describe

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Language(s): eng - English
 Dates: 2017-09-062017-11
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nrm.2017.71
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Title: Nature Reviews Molecular Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 18 (11) Sequence Number: - Start / End Page: 685 - 701 Identifier: -