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  General and selective brain connectivity alterations in essential tremor: A resting state fMRI study

Mueller, K., Jech, R., Hoskovcová, M., Ulmanová, O., Urgošík, D., Vymazal, J., et al. (2017). General and selective brain connectivity alterations in essential tremor: A resting state fMRI study. NeuroImage: Clinical, 16, 468-476. doi:10.1016/j.nicl.2017.06.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-E7C5-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B460-5
Genre: Journal Article

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 Creators:
Mueller, Karsten1, Author              
Jech, Robert2, Author
Hoskovcová, Martina2, Author
Ulmanová, Olga2, Author
Urgošík, Dušan3, Author
Vymazal, Josef3, Author
Růžička, Evžen2, Author
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
3Na Homolce Hospital, Prague, Czech Republic, ou_persistent22              

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Free keywords: Essential tremor; Magnetic resonance imaging; fMRI; Brain connectivity; Eigenvector centrality; Fahn-Tolosa-Marin Tremor Rating Scale
 Abstract: Although essential tremor is the most common movement disorder, there is little knowledge about the pathophysiological mechanisms of this disease. Therefore, we explored brain connectivity based on slow spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal in patients with essential tremor (ET). A cohort of 19 ET patients and 23 healthy individuals were scanned in resting condition using functional magnetic resonance imaging (fMRI). General connectivity was assessed by eigenvector centrality (EC) mapping. Selective connectivity was analyzed by correlations of the BOLD signal between the preselected seed regions and all the other brain areas. These measures were then correlated with the tremor severity evaluated by the Fahn-Tolosa-Marin Tremor Rating Scale (FTMTS). Compared to healthy subjects, ET patients were found to have lower EC in the cerebellar hemispheres and higher EC in the anterior cingulate and in the primary motor cortices bilaterally. In patients, the FTMTS score correlated positively with the EC in the putamen. In addition, the FTMTS score correlated positively with selective connectivity between the thalamus and other structures (putamen, pre-supplementary motor area (pre-SMA), parietal cortex), and between the pre-SMA and the putamen. We observed a selective coupling between a number of areas in the sensorimotor network including the basal ganglia and the ventral intermediate nucleus of thalamus, which is widely used as neurosurgical target for tremor treatment. Finally, ET was marked by suppression of general connectivity in the cerebellum, which is in agreement with the concept of ET as a disorder with cerebellar damage.

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Language(s): eng - English
 Dates: 2017-05-222017-02-092017-06-012017-06-02
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2017.06.004
PMID: 28913163
PMC: PMC5587870
Other: eCollection 2017
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Project name : -
Grant ID : 16-13323S
Funding program : -
Funding organization : Czech Science Foundation GAČR
Project name : -
Grant ID : AZV16-28119A
Funding program : -
Funding organization : Czech Agency for Health Research
Project name : Progres Q27/LF1
Grant ID : -
Funding program : -
Funding organization : Charles University

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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 16 Sequence Number: - Start / End Page: 468 - 476 Identifier: ISSN: 2213-1582
CoNE: /journals/resource/2213-1582