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  Electrophysiology of GABAA and GABAB receptor subtypes.

Bormann, J. (1988). Electrophysiology of GABAA and GABAB receptor subtypes. Trends in Neurosciences, 11(3), 112-116. doi:10.1016/0166-2236(88)90156-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-E83B-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-E83E-3
Genre: Journal Article

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Bormann, J.1, Author              
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1Abteilung Zellphysiologie, MPI for biophysical chemistry, Max Planck Society, ou_578558              

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 Abstract: The participation of GABA receptors in the inhibitory transmission at mammalian central synapses was demonstrated experimentally two decades ago. Whilst the ‘classical’ action of GABA involves the opening of Cl− channels, pharmacologically distinct effects of GABA on cation channels were detected later. This led to the notion of GABAA and GABAB receptor subtypes. The GABAA receptor complex contains an integral Cl− ionophore, whereas GABAB receptors couple to Ca2+ and K+ channels via GTP-binding proteins. The physiological and pharmacological properties of GABAA and GABAB receptors will be discussed below in terms of ion channels that are activated by the two receptor subtypes.

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Language(s): eng - English
 Dates: 1988-03
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/0166-2236(88)90156-7
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Title: Trends in Neurosciences
Source Genre: Journal
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Pages: - Volume / Issue: 11 (3) Sequence Number: - Start / End Page: 112 - 116 Identifier: -