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  A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

Kaelin, S., Becker, M., Ott, V. B., Serr, I., Hosp, F., Mollah, M. M. H., et al. (2017). A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metabolism, 26(3), 475-492.e7. doi:10.1016/j.cmet.2017.08.008.

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 Creators:
Kaelin, Stefanie1, Author
Becker, Maike1, Author
Ott, Verena B.1, Author
Serr, Isabelle1, Author
Hosp, Fabian2, Author              
Mollah, Mohammad M. H.1, Author
Keipert, Susanne1, Author
Lamp, Daniel1, Author
Rohner-Jeanrenaud, Francoise1, Author
Flynn, Victoria K.1, Author
Scherm, Martin G.1, Author
Nascimento, Lucas F. R.1, Author
Gerlach, Katharina1, Author
Popp, Vanessa1, Author
Dietzen, Sarah1, Author
Bopp, Tobias1, Author
Krishnamurthy, Purna1, Author
Kaplan, Mark H.1, Author
Serrano, Manuel1, Author
Woods, Stephen C.1, Author
Tripal, Philipp1, AuthorPalmisano, Ralf1, AuthorJastroch, Martin1, AuthorBlueher, Matthias1, AuthorWolfrum, Christian1, AuthorWeigmann, Benno1, AuthorZiegler, Anette-Gabriele1, AuthorMann, Matthias2, Author              Tschoep, Matthias H.1, AuthorDaniel, Carolin1, Author more..
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: DIET-INDUCED THERMOGENESIS; BODY CRYOSTIMULATION TREATMENT; CONSTITUTIVELY ACTIVE STAT6; REG CELLS; IN-VIVO; GENE-EXPRESSION; PPAR-GAMMA; BROWN FAT; IL-4; MICECell Biology; Endocrinology & Metabolism;
 Abstract: Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4(+) T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss-and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3(+) Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
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Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
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Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 26 (3) Sequence Number: - Start / End Page: 475 - 492.e7 Identifier: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928