hide
Free keywords:
-
Abstract:
Naturally occurring neuronal cell death has been
investigated in the electromotor system of Torpedo marmorata
and compared with neuronal death seen in explant cultures
of tissues from T. marmorata electric lobe. One objective
of the study was to determine whether cell death in
vitro was morphologically the same as cell death in vivo
and to substantiate the validity of using in vitro models
for studying naturally occurring cell death. Sequences of
degeneration in vitro and in vivo have been established
and compared: a single morphological sequence best represents
this form of cell death in both conditions. In vivo,
dying neurons are seen at all depths of the electric lobe
indicating the involvement of different generations. Retrograde
degeneration appears to be the first sign of cell death.
