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  Frontal assessment battery in Parkinson’s disease: Validity and morphological correlates

Bezdicek, O., Růžička, F., Mazancova, A. F., Roth, J., Dušek, P., Mueller, K., et al. (2017). Frontal assessment battery in Parkinson’s disease: Validity and morphological correlates. Journal of the International Neuropsychological Society, 23(8), 675-684. doi:10.1017/S1355617717000522.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F00A-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B450-7
Genre: Journal Article

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 Creators:
Bezdicek, Ondrej1, Author
Růžička, Filip1, Author
Mazancova, Andela Fendrych1, Author
Roth, Jan1, Author
Dušek, Pavel1, Author
Mueller, Karsten2, Author              
Růžička , Evžen1, Author
Jech, Robert1, Author
Affiliations:
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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 Abstract: Objectives: Executive dysfunction is a common feature in Parkinson’s disease (PD). However, there is a lack of brief validated instruments for executive dysfunction in PD. Methods: The aim of the present study was to assess the relation of Frontal Assessment Battery (FAB) scores to age and education, to verify the utility of FAB in the evaluation of executive dysfunction in PD and to differentiate between controls (n=41), PD patients with normal cognition (PD-NC; n=41; Hoehn and Yahr stages 2–3) and PD with mild cognitive impairment (PD-MCI; n=32; Hoehn and Yahr stages 2–3). In addition, we studied the relation between voxel-based morphometric (VBM) data and FAB results in PD. Results: We found that FAB scores are significantly related to age and education. The FAB has shown discriminative validity for the differentiation of PD-MCI from PD-NC and controls (area under the curve >.80). Also, the VBM analysis revealed lower FAB scores are specifically related to lower gray matter density in the right ventromedial prefrontal areas and precuneus. Conclusions: The FAB can be recommended as a valid instrument for PD-MCI Level I screening. FAB is sensitive to frontal lobe involvement in PD as reflected by lower gray matter density in prefrontal areas.

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Language(s): eng - English
 Dates: 2017-07-182017-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1017/S1355617717000522
PMID: 28716165
Other: Epub 2017
 Degree: -

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Project name : PROGRES Q27
Grant ID : -
Funding program : -
Funding organization : Charles University
Project name : PROGRES Q06/LF1
Grant ID : -
Funding program : -
Funding organization : Charles University
Project name : -
Grant ID : 16-13323S
Funding program : -
Funding organization : Czech Science Foundation GAČR
Project name : -
Grant ID : 16-01781S
Funding program : -
Funding organization : Czech Science Foundation “Cognitive Predictors of Neurodegeneration”

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Title: Journal of the International Neuropsychological Society
Source Genre: Journal
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Publ. Info: New York, NY : Cambridge University Press
Pages: - Volume / Issue: 23 (8) Sequence Number: - Start / End Page: 675 - 684 Identifier: ISSN: 1355-6177
CoNE: https://pure.mpg.de/cone/journals/resource/954925343773