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  How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Franz, J., Tarantola, M., & Riethmüller, C. (2017). How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation. Biochemical Society Transactions, 45(4), 999-1006. doi:10.1042/BST20170163.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F133-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3956-F
Genre: Journal Article

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 Creators:
Franz, Jonas1, Author              
Tarantola, Marco2, Author              
Riethmüller, C., Author
Affiliations:
1Research Group Theoretical Neurophysics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063289              
2Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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Free keywords: atherosclerosis; cholesterol; inflammation; membranes; multiple sclerosis; tetraspanins
 Abstract: Tetraspanins are ubiquitous membrane proteins that induce local membrane curvature and hence co-ordinate cell-to-cell contacts. This review highlights their role in inflammation, which requires control of the nano-architecture of attachment sites between endothelial cells and leukocytes. The active role of endothelial cells in preparing for transmigration of leukocytes and determining the severity of an inflammation is often underscored. A clear hint to endothelial pre-activation is their ability to protrude clustered adhesion proteins upward prior to leukocyte contact. The elevation of molecular adhesive platforms toward the blood stream is crucially dependent on tetraspanins. In addition, leukocytes require tetraspanins for their activation. The example of the B-cell receptor is referenced in some detail here, since it provides deeper insights into the receptor-coreceptor interplay. To lift the role of tetraspanins from an abstract model of inflammation toward a player of clinical significance, two pathologies are analyzed for the known contributions of tetraspanins. The recent publication of the first crystal structure of a full-length tetraspanin revealed a cholesterol-binding site, which provides a strong link to the pathophysiological condition of atherosclerosis. Dysregulation of the inflammatory cascade in autoimmune diseases by endothelial cells is exemplified by the involvement of tetraspanins in multiple sclerosis.

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Language(s): eng - English
 Dates: 2017-07-142017-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1042/BST20170163
 Degree: -

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Title: Biochemical Society Transactions
Source Genre: Journal
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Pages: - Volume / Issue: 45 (4) Sequence Number: - Start / End Page: 999 - 1006 Identifier: -