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  Automatized smoking-related action schemata are reflected by reduced fMRI activity in sensorimotor brain regions of smokers

Isik, A. I., Naumer, M. J., Kaiser, J., Buschenlange, C., Wiesmann, S., Czoschke, S., et al. (2017). Automatized smoking-related action schemata are reflected by reduced fMRI activity in sensorimotor brain regions of smokers. NeuroImage: Clinical, 15, 753-760. doi:10.1016/j.nicl.2017.06.021.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F265-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F266-5
Genre: Journal Article

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Isik et al. 2017.pdf (Publisher version), 496KB
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2017
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© 2017 The Authors. Published by Elsevier Inc.

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 Creators:
Isik, Ayse Ilkay1, 2, Author              
Naumer, Marcus J.2, Author
Kaiser, Jochen2, Author
Buschenlange, Christian2, Author
Wiesmann, Sandro2, Author
Czoschke, Stefan2, 3, Author              
Yalachkov, Yavor2, 4, Author
Affiliations:
1Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
2Institute of Medical Psychology, Goethe-University , Frankfurt am Main, Germany, ou_persistent22              
3Department of Music, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421696              
4Department of Neurology, University Hospital Frankfurt am Main, Frankfurt am Main, Germany, ou_persistent22              

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 Abstract: In the later stages of addiction, automatized processes play a prominent role in guiding drug-seeking and drug-taking behavior. However, little is known about the neural correlates of automatized drug-taking skills and drug-related action knowledge in humans. We employed functional magnetic resonance imaging (fMRI) while smokers and non-smokers performed an orientation affordance task, where compatibility between the hand used for a behavioral response and the spatial orientation of a priming stimulus leads to shorter reaction times resulting from activation of the corresponding motor representations. While non-smokers exhibited this behavioral effect only for control objects, smokers showed the affordance effect for both control and smoking-related objects. Furthermore, smokers exhibited reduced fMRI activation for smoking-related as compared to control objects for compatible stimulus-response pairings in a sensorimotor brain network consisting of the right primary motor cortex, supplementary motor area, middle occipital gyrus, left fusiform gyrus and bilateral cingulate gyrus. In the incompatible condition, we found higher fMRI activation in smokers for smoking-related as compared to control objects in the right primary motor cortex, cingulate gyrus, and left fusiform gyrus. This suggests that the activation and performance of deeply embedded, automatized drug-taking schemata employ less brain resources. This might reduce the threshold for relapsing in individuals trying to abstain from smoking. In contrast, the interruption or modification of already triggered automatized action representations require increased neural resources.

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Language(s): eng - English
 Dates: 2017-05-242017-03-032017-06-162017-06-17
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nicl.2017.06.021
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Title: NeuroImage: Clinical
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 15 Sequence Number: - Start / End Page: 753 - 760 Identifier: ISSN: 2213-1582
CoNE: /journals/resource/2213-1582