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  Charge matters: modulating secondary interactions in hyaluronan hydrogels

Hegger, P., Kupka, J., Baykal Minsky, B., Schädel, N., Petri, N., Laschat, S., et al. (2017). Charge matters: modulating secondary interactions in hyaluronan hydrogels. ChemistrySelect, 2(25), 7701-7705. doi:10.1002/slct.201701908.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F30F-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1107-0
Genre: Journal Article

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 Creators:
Hegger, Patricia1, 2, Author              
Kupka, Julia, Author
Baykal Minsky, Burcu1, 2, Author              
Schädel, Nicole, Author
Petri, Nadja, Author
Laschat, Sabine, Author
Böhm, Heike1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: carbohydrates; electrostatic interaction; hyaluronan; polyelectrolyte hydrogel; synthetic biology
 Abstract: Hyaluronic acid (HA) is a vital, functional component of the extracellular matrix (ECM). Following a synthetic biology approach, we designed polyelectrolyte hydrogels composed of HA as a polymeric backbone interconnected by short covalent crosslinkers. Utilizing a thiol-Michael addition, defined network structures are created, which can be modulated by the aromatic core and charge of the crosslinkers. With increasing negative network charge, varied both through the charge of the crosslinker and the degree of functionalization of the HA chain, the Young's modulus of the hydrogels decreases linearly as swelling ratios increase. Interestingly, secondary interactions with aromatic crosslinkers are stronger for elastin inspired crosslinkers with a pyridinium core compared to analogous triazolium crosslinkers. Based on the defined covalent interconnectivity of these HA-hydrogels, we were able to demonstrate the specific electrostatic and aromatic interactions induced by different short crosslinkers.

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Language(s): eng - English
 Dates: 2017-08-252017-08-212017-08-302017-09-012017-08-31
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/slct.201701908
 Degree: -

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Title: ChemistrySelect
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 2 (25) Sequence Number: - Start / End Page: 7701 - 7705 Identifier: Other: 2365-6549
CoNE: https://pure.mpg.de/cone/journals/resource/2365-6549