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  Increased retention of calcium in the dendrites of long-term potentiated CA1 neurons of the hippocampal slice. A combined electrophysiological and electron histochemical study.

Kuhnt, U., Mihaly, A., Siklos, L., & Joo, F. (1988). Increased retention of calcium in the dendrites of long-term potentiated CA1 neurons of the hippocampal slice. A combined electrophysiological and electron histochemical study. Histochemistry, 90(3), 185-193. doi:10.1007/BF00492506.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F367-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F369-A
Genre: Journal Article

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 Creators:
Kuhnt, U.1, Author              
Mihaly, A.1, Author              
Siklos, L.1, Author              
Joo, F., Author
Affiliations:
1Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society, ou_578620              

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 Abstract: In view of the importance of calcium in the induction of long-term potentiation (LTP), experiments were carried out to localize calcium at the electron microscopic level in the CA1 region of guinea pig hippocampal slices, following high-frequency stimulation of the Schaffer collaterals. Apart from the ultrastructural localization, a semi-quantitative method was used to count the calcium-containing deposits in electron micrographs. Significantly more calcium-containing deposits were seen in the dendrites of the stratum radiatum in slices with LTP than in those without it. A moderate increase of the extradendritic deposits was observed, too. The calcium content of the deposits was determined by means of EGTA incubation and X-ray analysis. The presented results, together with the relevant literature data, underline the importance of calcium-activated processes in postsynaptic structures probably involved in the generation of LTP.

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Language(s): eng - English
 Dates: 1988-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/BF00492506
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Title: Histochemistry
Source Genre: Journal
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Pages: - Volume / Issue: 90 (3) Sequence Number: - Start / End Page: 185 - 193 Identifier: -