English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Molecular characterization of a recently identified circovirus in zebra finches (Taeniopygia guttata) associated with immunosuppression and opportunistic infections

Rinder, M., Schmitz, A., Peschel, A., Wörle, B., Gerlach, H., & Korbel, R. (2017). Molecular characterization of a recently identified circovirus in zebra finches (Taeniopygia guttata) associated with immunosuppression and opportunistic infections. Avian Pathology, 46(1), 106-116. doi:10.1080/03079457.2016.1223272.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Rinder, M., Author
Schmitz, Anna, Author
Peschel, Andrea, Author
Wörle, Barbara1, Author           
Gerlach, H., Author
Korbel, R., Author
Affiliations:
1Max Planck Institut für Ornithologie, Max Planck Society, Eberhard-Gwinner-Straße, Seewiesen, 82319 Starnberg, DE, ou_2149683              

Content

show
hide
Free keywords: -
 Abstract: A recently identified circovirus (family Circoviridae) was detected in 14 zebra finches (Taeniopygia guttata) from seven aviaries and hobbyist breeders using polymerase chain reaction followed by sequencing. Full genome sequences of virus strains from six zebra finches consistently revealed characteristic circoviral genomic features such as a stem-loop structure and two major open reading frames (ORFs) encoding the replication-associated protein and the putative capsid protein. One further ORF encoding a protein of unknown function was additionally identified in all six genomes. Based on full genome nucleotide comparison, zebra finch circovirus was most similar to Finch circovirus originating from a Gouldian finch (Chloebia gouldiae) sharing 78% nucleotide identity. High genetic diversity was detected in the circoviruses from individual zebra finches. Comparison of the six full genome sequences revealed two genetic subgroups, which shared pairwise nucleotide identities between 91.4% and 92.7%. Analyses including partial sequences of the replication-associated protein gene of the zebra finch circovirus strains from all 14 birds supported the existence of two main clusters. Clinical diseases associated with circovirus infection were found in nestlings, fledglings and adult birds and varied from mild to severe with high mortality caused by secondary infections. Macrorhabdus ornithogaster was the most frequently detected opportunistic pathogen. Feathering disorders were seen in two birds. Lymphocytic depletion of the spleen and leukocytopaenia were detected in individual birds, suggesting immunosuppression and a pathogenesis common to circovirus infections in other birds.

Details

show
hide
Language(s):
 Dates: 2017-01-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000392623900013
DOI: 10.1080/03079457.2016.1223272
ISSN: 0307-9457
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Avian Pathology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 46 (1) Sequence Number: - Start / End Page: 106 - 116 Identifier: -