日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
 
 
ダウンロード電子メール
  Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke

Hope, T. M. H., Leff, A. P., Prejawa, S., Bruce, R., Haigh, Z., Lim, L., Ramsden, S., Oberhuber, M., Ludersdorfer, P., Crinion, J., Seghier, M. L., & Price, C. J. (2017). Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke. Brain, 140(6), 1718-1728. doi:10.1093/brain/awx086.

Item is

基本情報

表示: 非表示:
資料種別: 学術論文

ファイル

表示: ファイル

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Hope, Thomas M. H., 著者
Leff, Alex P., 著者
Prejawa, Suse1, 著者           
Bruce, Rachel, 著者
Haigh, Zula, 著者
Lim, Louise, 著者
Ramsden, Sue, 著者
Oberhuber, Marion, 著者
Ludersdorfer, Philipp, 著者
Crinion, Jenny, 著者
Seghier, Mohamed L., 著者
Price, Cathy J., 著者
所属:
1External Organizations, ou_persistent22              

内容説明

表示:
非表示:
キーワード: Stroke; Language; Chronic aphasia; Recovery; Decline; MRI
 要旨: Stroke survivors with acquired language deficits are commonly thought to reach a ‘plateau’ within a year of stroke onset, after which their residual language skills will remain stable. Nevertheless, there have been reports of patients who appear to recover over years. Here, we analysed longitudinal change in 28 left-hemisphere stroke patients, each more than a year post-stroke when first assessed—testing each patient’s spoken object naming skills and acquiring structural brain scans twice. Some of the patients appeared to improve over time while others declined; both directions of change were associated with, and predictable given, structural adaptation in the intact right hemisphere of the brain. Contrary to the prevailing view that these patients’ language skills are stable, these results imply that real change continues over years. The strongest brain–behaviour associations (the ‘peak clusters’) were in the anterior temporal lobe and the precentral gyrus. Using functional magnetic resonance imaging, we confirmed that both regions are actively involved when neurologically normal control subjects name visually presented objects, but neither appeared to be involved when the same participants used a finger press to make semantic association decisions on the same stimuli. This suggests that these regions serve word-retrieval or articulatory functions in the undamaged brain. We teased these interpretations apart by reference to change in other tasks. Consistent with the claim that the real change is occurring here, change in spoken object naming was correlated with change in two other similar tasks, spoken action naming and written object naming, each of which was independently associated with structural adaptation in similar (overlapping) right hemisphere regions. Change in written object naming, which requires word-retrieval but not articulation, was also significantly more correlated with both (i) change in spoken object naming; and (ii) structural adaptation in the two peak clusters, than was change in another task—auditory word repetition—which requires articulation but not word retrieval. This suggests that the changes in spoken object naming reflected variation at the level of word-retrieval processes. Surprisingly, given their qualitatively similar activation profiles, hypertrophy in the anterior temporal region was associated with improving behaviour, while hypertrophy in the precentral gyrus was associated with declining behaviour. We predict that either or both of these regions might be fruitful targets for neural stimulation studies (suppressing the precentral region and/or enhancing the anterior temporal region), aiming to encourage recovery or arrest decline even years after stroke occurs.

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2017-01-272016-07-142017-02-102017-04-242017-06-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1093/brain/awx086
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示:

出版物 1

表示:
非表示:
出版物名: Brain
  その他 : Brain
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London : Macmillan
ページ: - 巻号: 140 (6) 通巻号: - 開始・終了ページ: 1718 - 1728 識別子(ISBN, ISSN, DOIなど): ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135