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  Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type.

Fischer, H. P., Doppl, W., Osborn, M., & Altmannsberger, M. (1988). Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type. Virchows Archiv B, 56(1), 71-76. doi:10.1007/BF02890004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F816-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-F818-7
Genre: Journal Article

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Fischer, H. P., Author
Doppl, W., Author
Osborn, M.1, Author              
Altmannsberger, M., Author
Affiliations:
1Department of Biochemistry and Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578618              

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 Abstract: A combined hepatocellular-cholangiocarcinoma (CHC) of transitional subtype and the surrounding cirrhotic liver tissue were investigated immunocytochemically by monoclonal antibodies specific for each of the keratin polypeptides 7, 8, 18 and 19. Different keratin subsets were found in different parts of the tumour. The hepatocellular component reveals keratins 8 and 18, with the bordering cells of trabecular formations additionally expressing keratins 7 and 19. The same keratins i.e. 7, 8, 18, 19 were found in normal bile duct epithelium as well as in cholangiocarcinomatous and transitional areas of hepatocellular and cholangiocellular differentiation. Normal hepatocytes express only keratin 8 and 18. In cirrhotic liver some modified hepatocytes additionally express keratin 7. When ductal transformation is observed in the marginal parts of portal tracts and fibrous septa the keratin polypeptide pattern mimics that of bile duct epithelium. The cholangiocellular metaplasia of hepatocytes observed here correlates well with findings in hepato-organogenesis and hepatocarcinogenesis and suggests that the transitional subtype of combined hepatocellular-cholangiocarcinoma is a variant of hepatocellular carcinoma.

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Language(s): eng - English
 Dates: 1988-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/BF02890004
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Title: Virchows Archiv B
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 56 (1) Sequence Number: - Start / End Page: 71 - 76 Identifier: -