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  Impaired competence in flagellar mutants of Bacillus subtilis is connected to the regulatory network governed by DegU

Hölscher, T., Schiklang, T., Dragoš, A., Dietel, A.-K., Kost, C., & Kovács, Á. T. (2018). Impaired competence in flagellar mutants of Bacillus subtilis is connected to the regulatory network governed by DegU. Environmental Microbiology Reports, 10(1), 23-32. doi:10.1111/1758-2229.12601.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-F847-C Version Permalink: https://hdl.handle.net/21.11116/0000-0009-30F0-1
Genre: Journal Article

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KOS022s1.pdf (Supplementary material), 153KB
 
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 Creators:
Hölscher, Theresa1, Author           
Schiklang, Tina, Author
Dragoš, Anna, Author
Dietel, Anne-Kathrin1, 2, Author           
Kost, Christian2, Author           
Kovács, Ákos T., Author
Affiliations:
1IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society, Jena, DE, ou_421900              
2Research Group Dr. C. Kost, Experimental Ecology and Evolution, Department of Bioorganic Chemistry, Prof. Dr. W. Boland, MPI for Chemical Ecology, Max Planck Society, ou_421906              

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 Abstract: The competent state is a developmentally distinct phase, in which bacteria are able to take up and integrate exogenous DNA into their genome. Bacillus subtilis is one of the naturally competent bacterial species and the domesticated laboratory strain 168 is easily transformable. In this study, we report a reduced transformation frequency of B. subtilis mutants lacking functional and structural flagellar components. This includes hag, the gene encoding the flagellin protein forming the filament of the flagellum. We confirm that the observed decrease of the transformation frequency is due to reduced expression of competence genes, particularly of the main competence regulator gene comK. The impaired competence is due to an increase in the phosphorylated form of the response regulator DegU, which is involved in regulation of both flagellar motility and competence. Altogether, our study identified a close link between motility and natural competence in B. subtilis suggesting that hindrance in motility has great impact on differentiation of this bacterium not restricted only to the transition towards sessile growth stage.

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 Dates: 2017-11-102017-12-042018-02
 Publication Status: Issued
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 Identifiers: Other: KOS022
DOI: 10.1111/1758-2229.12601
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Title: Environmental Microbiology Reports
  Abbreviation : Environ Microbiol Rep
Source Genre: Journal
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Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: 10 (1) Sequence Number: - Start / End Page: 23 - 32 Identifier: ISSN: 1758-2229
CoNE: https://pure.mpg.de/cone/journals/resource/1758-2229