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  In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex

Trampel, R., Bazin, P.-L., Pine, K., & Weiskopf, N. (2019). In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex. NeuroImage, 197, 707-715. doi:10.1016/j.neuroimage.2017.09.037.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-FD80-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4F78-D
Genre: Journal Article

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 Creators:
Trampel, Robert1, Author              
Bazin, Pierre-Louis1, 2, 3, Author              
Pine, Kerrin1, Author              
Weiskopf, Nikolaus1, Author              
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              

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Free keywords: Cortical layers; In-vivo histology; Laminar depth coordinate system; Stria of Gennari
 Abstract: The human neocortex is organized radially into six layers which differ in their myelination and the density and arrangement of neuronal cells. This cortical cyto- and myeloarchitecture plays a central role in the anatomical and functional neuroanatomy but is primarily accessible through invasive histology only. To overcome this limitation, several non-invasive MRI approaches have been, and are being, developed to resolve the anatomical cortical layers. As a result, recent studies on large populations and structure-function relationships at the laminar level became possible. Early proof-of-concept studies targeted conspicuous laminar structures such as the stria of Gennari in the primary visual cortex. Recent work characterized the laminar structure outside the visual cortex, investigated the relationship between laminar structure and function, and demonstrated layer-specific maturation effects. This paper reviews the methods and in-vivo MRI studies on the anatomical layers in the human cortex based on conventional and quantitative MRI (excluding diffusion imaging). A focus is on the related challenges, promises and potential future developments. The rapid development of MRI scanners, motion correction techniques, analysis methods and biophysical modeling promise to overcome the challenges of spatial resolution, precision and specificity of systematic imaging of cortical laminae.

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Language(s): eng - English
 Dates: 2017-09-132017-04-142017-09-192017-09-202019-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2017.09.037
PMID: 28942063
Other: Epub 2017
 Degree: -

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Project name : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : FP7 (ERC-2013-CoG)
Funding organization : European Research Council (ERC)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial /NISCI
Grant ID : 681094
Funding program : Horizon 2020 (H2020-PHC-2014-2015)
Funding organization : European Union (EU)
Project name : Talking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Funding program : Funding Programme 7 (FP7-HEALTH-2013-INNOVATION-1)
Funding organization : European Union (EU)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 197 Sequence Number: - Start / End Page: 707 - 715 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166