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Abstract:
Abstract. Some patients with liver dysfunction show a marked hypertriglyceridaemia, a phenomenon most frequently accompanied by cholestasis.
In this report we have identified, isolated and characterized an abnormally large (300–700 Å), triglyceride rich, low density lipoprotein, (d 1.019-1.063 g/ml) designated β-lipoprotein (β2-LP), from the plasma of patients with hypertriglyceridaemia secondary to liver disease. The βa-LP differs significantly in its percent composition and protein moiety from the unique lipoprotein-X (LP-X) specific for cholestasis and also from normal β-lipoproteins, both of which are also present in the patients LDL fraction. Furthermore, some evidence is provided suggesting that the β2-LP is likely to represent an intermediate particle of chylomicron metabolism, which accumulates in this disease due to a markedly diminished hepatic lipase activity.
