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  Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster

Helfrich-Förster, C., Wulf, J., & de Belle, J. S. (2002). Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster. Journal of Neurogenetics, 16(2), 73.

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Helfrich-Förster, C., Author
Wulf, J.1, Author              
de Belle, J. S., Author
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1Department of Molecular Ecology, Max Planck Institute for Marine Microbiology, Max Planck Society, ou_2481696              

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Free keywords: corpora pedunculata; hydroxyurea; period gene; mushroom body mutants; pigment-dispersing hormone; immunohistochemistry
 Abstract: Whether or not mechanisms underlying circadian locomotor rhythms and learning are related anatomically through the mushroom bodies (MBs) was investigated by monitoring behavioral rhythmicity in flies with MB lesions induced by chemical ablation and by mutations in five different genes. All flies tested were later examined histologically to assess (1) MB neuroanatomy, and (2) the condition of the putative pacemaker cells - the ventral Lateral Neurons (LN(v)s) and their terminals that project to the vicinity of the MB calyces. All groups of flies had normal rhythms except for mushroom body miniature (mbm; only in a wild-type Berlin genetic background) and mushroom body defect (mud). MB ablation had no effect on the gender-specific differences in the rhythmic activity profile that are typical of wild-type flies. However, ablated males had a slightly longer period than untreated males and were more active under constant dark conditions. LN(v)s and their arborization patterns appeared normal in MB-ablated and in most mutant flies. Activity defects of mbm flies were attributed to genetic background rather than to the mutation alone. Misrouted LNv projections and similar to14% arrhythmia of mud flies were uncorrelated and attributed to pleiotropy rather than to specific effects of MB lesions. Our results imply that MBs are not involved in circadian activity rhythms but that they do have an inhibitory effect on activity levels of male flies.

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Language(s): eng - English
 Dates: 2002-04
 Publication Status: Published in print
 Pages: 37
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13840
ISI: 000177327000001
 Degree: -

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Title: Journal of Neurogenetics
  Other : J. Neurogenet.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 16 (2) Sequence Number: - Start / End Page: 73 Identifier: ISSN: 0167-7063
CoNE: https://pure.mpg.de/cone/journals/resource/954925483672