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  Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis.

Dianzani, C., Bellavista, E., Liepe, J., Verderio, C., Martucci, M., Santoro, A., et al. (2017). Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis. Scientific Reports, 7: 43718. doi:10.1038/srep43718.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-FDFA-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-FDFE-E
Genre: Journal Article

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 Creators:
Dianzani, C., Author
Bellavista, E., Author
Liepe, J.1, Author              
Verderio, C., Author
Martucci, M., Author
Santoro, A., Author
Chiocchetti, A., Author
Gigliotti, C. L., Author
Boggio, E., Author
Ferrara, B., Author
Riganti, L., Author
Keller, C., Author
Janek, K., Author
Niewienda, A., Author
Fenoglio, C., Author
Sorosina, M., Author
Cantello, R., Author
Kloetzel, P. M., Author
Stumpf, M. P. H., Author
Paul, F., Author
Ruprecht, K., AuthorGalimberti, D., AuthorBoneschi, F. M., AuthorComi, C., AuthorDianzani, U., AuthorMishto, M., Author more..
Affiliations:
1Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_2466694              

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 Abstract: Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby producing fragments with novel chemotactic activity. Furthermore, osteopontin reduces the release of proteasomes in the extracellular space. The latter phenomenon seems to occur in vivo in multiple sclerosis, where it reflects the remission/relapse alternation. The extracellular proteasome-mediated inflammatory pathway may represent a general mechanism to control inflammation in inflammatory diseases.

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Language(s): eng - English
 Dates: 2017-03-09
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/srep43718
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Title: Scientific Reports
Source Genre: Journal
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Pages: 12 Volume / Issue: 7 Sequence Number: 43718 Start / End Page: - Identifier: -