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  Cross-bridge conformation as revealed by x-ray diffraction studies on insect flight muscles with ATP analogues

Goody, R. S., Holmes, K. C., Mannherz, H. G., Barrington Leigh, J., & Rosenbaum, G. (1975). Cross-bridge conformation as revealed by x-ray diffraction studies on insect flight muscles with ATP analogues. Biophysical Journal, 15(7), 687-705. doi:10.1016/S0006-3495(75)85848-6.

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 Creators:
Goody, Roger S.1, Author           
Holmes, Kenneth C.2, Author           
Mannherz, Hans Georg1, Author           
Barrington Leigh, J.3, Author           
Rosenbaum, G.3, Author           
Affiliations:
1Abt. III: Physikalische Biochemie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753289              
2Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
3Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: The effects of three ATP analogues, alpha,beta-methylene-ATP [ATP(alpha,beta-CH1)], adenosine 5'-0-(3-thiotrophosphate) [ATP(gamma-S)], and beta,gamma-amino-ATP [ATP(beta,gamma-NH)] at various concentrations and temperatures on the X-ray fiber diagrams of glycerinated flight muscles from a water bug (Lethocerus maximus) have been investigated. It is shown that the "relaxed" state can be obtained with all three analogues at high concentrations, the result being particularly clear with ATP(gamma-S). It is inferred that the binding of an ATP-like molecule suffices to produce the relaxed state. At low concentrations ATP(beta,gamma-NH) produces state intermediate between rigor and relaxed which is not simply a mixture of the two. The possible nature of the intermediate is discussed.

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Language(s): eng - English
 Dates: 2009-01-061975-07
 Publication Status: Published in print
 Pages: 19
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0006-3495(75)85848-6
 Degree: -

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Title: Biophysical Journal
  Other : Biophys. J.
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 15 (7) Sequence Number: - Start / End Page: 687 - 705 Identifier: Other: 0006-3495
CoNE: https://pure.mpg.de/cone/journals/resource/954925385117