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  Information theory and signal transduction systems: From molecular information processing to network inference.

McMahon, S. S., Sim, A., Filippi, S., Johnson, R., Liepe, J., Smith, D., et al. (2014). Information theory and signal transduction systems: From molecular information processing to network inference. Seminars in Cell and Developmental Biology, 35, 98-108. doi:10.1016/j.semcdb.2014.06.011.

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 Creators:
McMahon, S. S., Author
Sim, A., Author
Filippi, S., Author
Johnson, R., Author
Liepe, J.1, Author           
Smith, D., Author
Stumpf, M. P. H., Author
Affiliations:
1Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_2466694              

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Free keywords: Signal processing; Mutual information; Noise; Network inference; Experimental design
 Abstract: Sensing and responding to the environment are two essential functions that all biological organisms need to master for survival and successful reproduction. Developmental processes are marshalled by a diverse set of signalling and control systems, ranging from systems with simple chemical inputs and outputs to complex molecular and cellular networks with non-linear dynamics. Information theory provides a powerful and convenient framework in which such systems can be studied; but it also provides the means to reconstruct the structure and dynamics of molecular interaction networks underlying physiological and developmental processes. Here we supply a brief description of its basic concepts and introduce some useful tools for systems and developmental biologists. Along with a brief but thorough theoretical primer, we demonstrate the wide applicability and biological application-specific nuances by way of different illustrative vignettes. In particular, we focus on the characterisation of biological information processing efficiency, examining cell-fate decision making processes, gene regulatory network reconstruction, and efficient signal transduction experimental design.

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Language(s): eng - English
 Dates: 2014-06-192014-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.semcdb.2014.06.011
 Degree: -

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Title: Seminars in Cell and Developmental Biology
Source Genre: Journal
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Pages: - Volume / Issue: 35 Sequence Number: - Start / End Page: 98 - 108 Identifier: -