English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5

Lisboa, M. P., Khan, N., Martin, C., Xu, F.-F., Reppe, K., Geissner, A., et al. (2017). Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proceedings of the National Academy of Sciences of the United States of America, 114(42), 11063-11068. doi:10.1073/pnas.1706875114.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-08FE-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3FBF-3
Genre: Journal Article

Files

show Files
hide Files
:
article (publisher version).pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
article (publisher version).pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, Potsdam-Golm; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Lisboa, Marilda P.1, Author
Khan, Naeem1, Author              
Martin, Christopher1, Author              
Xu, Fei-Fei1, Author              
Reppe, Katrin, Author
Geissner, Andreas2, Author              
Govindan, Subramanian1, Author              
Witzenrath, Martin, Author
Pereira, Claney L.1, Author              
Seeberger, Peter H.3, Author              
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
2Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              
3Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

Content

show
hide
Free keywords: -
 Abstract: Glycoconjugate vaccines based on isolated capsular polysaccharide (CPS) save millions of lives annually by preventing invasive pneumococcal disease caused by Streptococcus pneumoniae. Some components of the S. pneumoniae glycoconjugate vaccine Prevnar13 that contains CPS antigens from 13 serotypes undergo modifications or degradation during isolation and conjugation, resulting in production problems and lower efficacy. We illustrate how stable, synthetic oligosaccharide analogs of labile CPS induce a specific protective immune response against native CPS using S. pneumoniae serotype 5 (ST-5), a problematic CPS component of Prevnar13. The rare aminosugar l-PneuNAc and a branched l-FucNAc present in the natural repeating unit (RU) are essential for antibody recognition and avidity. The epitope responsible for specificity differs from the part of the antigen that is stabilized by chemical modification. Glycoconjugates containing stable, monovalent synthetic oligosaccharide analogs of ST-5 CPS RU induced long-term memory and protective immune responses in rabbits superior to those elicited by the ST-5 CPS component in multivalent Prevnar13.

Details

show
hide
Language(s):
 Dates: 20172017-10-17
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.1706875114
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 114 (42) Sequence Number: - Start / End Page: 11063 - 11068 Identifier: ISSN: 0027-8424