English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Variability and order in cytoskeletal dynamics of motile amoeboid cells

Hsu, H.-F., Bodenschatz, E., Westendorf, C., Gholami, A., Pumir, A., Tarantola, M., et al. (2017). Variability and order in cytoskeletal dynamics of motile amoeboid cells. Physical Review Letters, 119(14): 148101. doi:10.1103/PhysRevLett.119.148101.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0E6F-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-371C-3
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hsu, Hsin-Fang1, Author              
Bodenschatz, Eberhard1, Author              
Westendorf, Christian1, Author              
Gholami, Azam1, Author              
Pumir, Alain1, Author              
Tarantola, Marco1, Author              
Beta, Carsten1, Author              
Affiliations:
1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

Content

show
hide
Free keywords: -
 Abstract: The chemotactic motion of eukaryotic cells such as leukocytes or metastatic cancer cells relies on membrane protrusions driven by the polymerization and depolymerization of actin. Here we show that the response of the actin system to a receptor stimulus is subject to a threshold value that varies strongly from cell to cell. Above the threshold, we observe pronounced cell-to-cell variability in the response amplitude. The polymerization time, however, is almost constant over the entire range of response amplitudes, while the depolymerization time increases with increasing amplitude. We show that cell-to-cell variability in the response amplitude correlates with the amount of Arp2/3, a protein that enhances actin polymerization. A time-delayed feedback model for the cortical actin concentration is consistent with all our observations and confirms the role of Arp2/3 in the observed cell-to-cell variability. Taken together, our observations highlight robust regulation of the actin response that enables a reliable timing of cell movement.

Details

show
hide
Language(s): eng - English
 Dates: 2017-10-062017-10-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1103/PhysRevLett.119.148101
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Physical Review Letters
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 5 Volume / Issue: 119 (14) Sequence Number: 148101 Start / End Page: - Identifier: -