Reconstructed ancestral enzymes reveal that negative selection drove the 
evolution of substrate specificity in ADP-dependent kinases

Castro-Fernandez, Víctor; Herrera-Morande, Alejandra; Zamora, Ricardo; Merino, Felipe; Gonzalez-Ordenes, Felipe; Padilla-Salinas, Felipe; Pereira, Humberto M.; Brandão-Neto , Jose; Garratt, Richard C.; Guixe, Victoria

doi:10.1074/jbc.M117.790865

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Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases

Castro-Fernandez, V., Herrera-Morande, A., Zamora, R., Merino, F., Gonzalez-Ordenes, F., Padilla-Salinas, F., et al. (2017). Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases. Journal of Biological Chemistry, 292(38), 15598-15610. doi:10.1074/jbc.M117.790865.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-045A-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-045B-C

Genre: Journal Article

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Creators:
Castro-Fernandez, Víctor¹, Author
Herrera-Morande, Alejandra¹, Author
Zamora, Ricardo¹, Author
Merino, Felipe², Author
Gonzalez-Ordenes, Felipe¹, Author
Padilla-Salinas, Felipe¹, Author
Pereira, Humberto M.¹, Author
Brandão-Neto , Jose¹, Author
Garratt, Richard C.¹, Author
Guixe, Victoria¹, Author

Affiliations:
1External Organizations, ou_persistent22
2Abt. III: Strukturbiochemie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_2040307

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Free keywords: archaea; crystal structure; phosphofructokinase; protein evolution; substrate specificity; ADP-dependent kinase; ancestral enzymes; glucokinase

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Language(s): eng - English

Dates: Date issued: 2017-09-22

Publication Status: Issued

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Rev. Type: Peer

Identifiers: DOI: 10.1074/jbc.M117.790865

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Title: Journal of Biological Chemistry

Other : J. Biol. Chem.

Source Genre: Journal

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Publ. Info: Baltimore, etc. : American Society for Biochemistry and Molecular Biology [etc.]

Pages: - Volume / Issue: 292 (38) Sequence Number: - Start / End Page: 15598 - 15610 Identifier: ISSN: 0021-9258
CoNE: https://pure.mpg.de/cone/journals/resource/954925410826