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  Prefrontal-parietal effective connectivity during working memory in older adults

Heinzel, S., Lorenz, R. C., Duong, Q.-L., Rapp, M. A., & Deserno, L. (2017). Prefrontal-parietal effective connectivity during working memory in older adults. Neurobiology of Aging, 57, 18-27. doi:10.1016/j.neurobiolaging.2017.05.005.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-08FC-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C623-6
Genre: Journal Article

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 Creators:
Heinzel, Stephan1, 2, 3, Author
Lorenz, Robert C.4, 5, Author
Duong, Quynh-Lam4, Author
Rapp, Michael A. 2, 6, Author
Deserno, Lorenz7, 8, Author           
Affiliations:
1Department of Psychology, FU Berlin, Germany, ou_persistent22              
2Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
3Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
5Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
6NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
8Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Aging; Dynamic causal modeling (DCM); Effective connectivity; Functional magnetic resonance imaging (fMRI); Working memory
 Abstract: Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM) load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20–32 years) and 32 older (60–75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age- and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.

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Language(s): eng - English
 Dates: 2017-03-242016-08-292017-05-022017-05-102017-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neurobiolaging.2017.05.005
PMID: 28578155
Other: Epub 2017
 Degree: -

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Project name : -
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Funding program : -
Funding organization : Studienstiftung des Deutschen Volkes
Project name : -
Grant ID : 01QG87164 ; 01GS08195 ; 01GQ0914
Funding program : -
Funding organization : German Ministry for Education and Research (BMBF)
Project name : Lern- und Gewöhnungsprozesse als Prädiktoren für die Entwicklung und Aufrechterhaltung alkoholbezogener Störungen / FOR 1617
Grant ID : RA 1047/2-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Human performance under multiple cognitive task requirements: From basic mechanisms to optimized task scheduling / SPP 1772
Grant ID : RA 1047/4-1 ; HE 7464/1-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 57 Sequence Number: - Start / End Page: 18 - 27 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902