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  Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., et al. (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proceedings of the National Academy of Sciences of the United States of America, 114(40), 10719-10724. doi:10.1073/pnas.1711233114.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AAD-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-0AAE-4
Genre: Journal Article

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https://doi.org/10.7272/Q6N58JH2 (Supplementary material)
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Data deposition: Normalized datasets related to this paper are available from the UCSF Data Sharing Service (Dash) at https://doi.org/10.7272/Q6N58JH2 and raw data have been deposited in the European Bioinformatics Institute (EMBL-EBI) database, https://www.ebi.ac.uk (accession no. ERP101460).

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 Creators:
Berer, Kerstin1, Author              
Gerdes, Lisa Ann2, Author
Cekanaviciute, Egle2, Author
Jia, Xiaoming2, Author
Xiao, Liang2, Author
Xia, Zhongkui2, Author
Liu, Chuan2, Author
Klotz, Luisa2, Author
Stauffer, Uta2, Author
Baranzini, Sergio E.2, Author
Kuempfel, Tania2, Author
Hohlfeld, Reinhard2, Author
Krishnamoorthy, Gurumoorthy1, Author              
Wekerle, Hartmut1, Author              
Affiliations:
1Emeritus Group: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2external, ou_persistent22              

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Free keywords: T-CELLS; PARKINSONS-DISEASE; MATURATION; GENETICSScience & Technology - Other Topics; gut microbiome; multiple sclerosis; experimental autoimmune; encephalomyelitis; twin study; germ-free mice;
 Abstract: There is emerging evidence that the commensal microbiota has a role in the pathogenesis of multiple sclerosis ( MS), a putative autoimmune disease of the CNS. Here, we compared the gut microbial composition of 34 monozygotic twin pairs discordant for MS. While there were no major differences in the overall microbial profiles, we found a significant increase in some taxa such as Akkermansia in untreated MS twins. Furthermore, most notably, when transplanted to a transgenic mouse model of spontaneous brain autoimmunity, MS twin-derived microbiota induced a significantly higher incidence of autoimmunity than the healthy twin-derived microbiota. The microbial profiles of the colonized mice showed a high intraindividual and remarkable temporal stability with several differences, including Sutterella, an organism shown to induce a protective immunoregulatory profile in vitro. Immune cells from mouse recipients of MS-twin samples produced less IL-10 than immune cells from mice colonized with healthy-twin samples. IL-10 may have a regulatory role in spontaneous CNS autoimmunity, as neutralization of the cytokine in mice colonized with healthy-twin fecal samples increased disease incidence. These findings provide evidence that MS-derived microbiota contain factors that precipitate an MS-like autoimmune disease in a transgenic mouse model. They hence encourage the detailed search for protective and pathogenic microbial components in human MS.

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Language(s): eng - English
 Dates: 2017-09-112017-10-03
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000412130500070
DOI: 10.1073/pnas.1711233114
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 114 (40) Sequence Number: - Start / End Page: 10719 - 10724 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230